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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ivm</journal-id><journal-title-group><journal-title xml:lang="ru">Международный вестник ветеринарии</journal-title><trans-title-group xml:lang="en"><trans-title>International Journal of Veterinary Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-2419</issn><publisher><publisher-name>SpbGUVM Publishing House</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52419/issn2072-2419.2022.4.380</article-id><article-id custom-type="elpub" pub-id-type="custom">ivm-1015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКУШЕРСТВО, ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OBSTETRICS, GYNECOLOGY</subject></subj-group></article-categories><title-group><article-title>Влияние кортикостероидов на морфобиохимический состав крови и воспроизводительную функцию у коров</article-title><trans-title-group xml:lang="en"><trans-title>The effect of corticosteroids on the morphobiochemical composition of blood and reproductive function in cows</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5485-4616</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaev</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> к.в.н., научный сотрудник </p></bio><bio xml:lang="en"><p> Candidate of Veterinary Sciences, Researcher</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт агробиотехнологий им. А.В. Журавского Коми научного центра УрО РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Zhuravsky Institute of Agrobiotechnologies of the Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>03</day><month>02</month><year>2023</year></pub-date><volume>0</volume><issue>4</issue><fpage>380</fpage><lpage>386</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Николаев С.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Николаев С.В.</copyright-holder><copyright-holder xml:lang="en">Nikolaev S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vetjournal.spbguvm.ru/jour/article/view/1015">https://vetjournal.spbguvm.ru/jour/article/view/1015</self-uri><abstract><p>В работе изучено влияние глюкокортикоидсодержащего препарата на морфобиохимический состав крови и воспроизводительную функцию у крупного рогатого скота. Установлено, что в послеродовом периоде на фоне применения кортикостероидов, в крови происходит снижение концентрации эозинофилов на 87,5% (Р≤0,05), при стабильном содержании тромбоцитов. У животных без гормональной терапии наблюдался рост уровня общего белка на 18,8% (Р≤0,01) при снижении альбумино-глобулинового коэффициента на 26,4% (Р≤0,01), чего не происходило при использовании кортикостероидов. В опытной группе присутствовало снижение концентрации магния на 18,1% (Р≤0,05), при стабильном уровне фосфора и кальция. Активность трансаминаз на фоне применения глюкокортикоидов не имела достоверных изменений, тогда как у контрольных животных наблюдали увеличение активности АсАТ на 29,5% (Р≤0,05). Уровень общих иммуноглобулинов у животных контрольной группы снижался на 77,4% (Р≤0,001), тогда как на фоне применения стероида показатель был выше в 3,9 раз (Р≤0,001). ЦИК мелкого размера в первой группе коров снижались на 58,8%, что ниже в 4,4 раза (Р≤0,05) по сравнению с контрольной группой, где наоборот показатель увеличился в 3,4 раза (Р≤0,05). Так же у контрольных коров наблюдалось уменьшение размера ЦИК, тогда как на фоне применения кортикостероидов наоборот наблюдалось их укрупнение на 83,8% (Р≤0,001). Оплодотворяемость животных по первому осеменению на фоне использования кортикостероидов была выше на 43,3%, при меньшей (на 0,57) кратности осеменений на оплодотворении и более коротком (на 19,2 дня; Р&lt;0,05) периоде бесплодия. Таким образом, использование глюкокортикоидов в послеродовом периоде положительно отразилось на метаболических процессах и способствовало оптимизации воспроизводительной функции у коров.</p></abstract><trans-abstract xml:lang="en"><p>The effect of the glucocorticoidcontaining drug on the morphobiochemical composition of blood and reproductive function in cattle was studied. It was found that against the background of treatment in the postpartum period with corticosteroids, the concentration of eosinophils in the blood decreases by 87.5% (P &lt;0.05), with a stable concentration of platelets. In animals without hormone therapy, an increase in the level of total protein was observed by 18.8% (P&lt;0.01) with a decrease in the albuminglobulin coefficient by 26.4% (P&lt;0.01), which was not observed when using corticosteroids. In the experimental group, the magnesium concentration decreased by 18.1% (P&lt;0.05), with a stable level of phosphorus and calcium. The activity of transaminases against the background of the use of glucocorticoids had no significant changes, whereas in control animals an increase in the activity of AsAT was observed by 29.5% (P &lt; 0.05). The level of total immunoglobulins in animals of the control group decreased by 77.4% (P≤0.001), whereas against the background of Cortexone use, the indicator was 3.9 times higher (P≤0.001). The small-sized CEC in the first group of cows decreased by 58.8%, which is 4.4 times lower (P&lt;0.05) compared to the control group, where, on the contrary, the indicator increased 3.4 times (P&lt;0.05). Similarly, in control cows, a decrease in the size of the CEC was observed, whereas against the background of the use of corticosteroids, on the contrary, their enlargement was observed by 83.8% (P≤0.001). The fertilization of animals after the first insemination against the background of the use of corticosteroids was 43.3% higher, with a lower (0.57) multiplicity of inseminations during fertilization and a shorter (19.2 days; P&lt;0.05) period of infertility. Thus, the use of glucocorticoids in the postpartum period had a positive effect on metabolic processes and contributed to the optimization of reproductive function in cows.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>крупный рогатый скот</kwd><kwd>послеродовой период</kwd><kwd>метаболизм</kwd><kwd>глюкокортикоиды</kwd><kwd>оплодотворяемость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cattle</kwd><kwd>postpartum period</kwd><kwd>metabolism</kwd><kwd>glucocorticoids</kwd><kwd>fertilization</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Николаев С.В. Эффективность глюкозы при внутрибрюшинном введении коровам с кетозом // Ветеринария. 2021. № 12. С. 44-49. 10.30896/0042-4846.2021.24.12.44-49</mixed-citation><mixed-citation xml:lang="en">Nikolaev S.V. The effectiveness of glucose in intraperitoneal administration to cows with ketosis // Veterinary medicine. 2021. 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