Poultry meat is in great demand in the food market. The main method of producing poultry meat is raising broilers. The growth of broiler chickens is largely determined by balanced feeding. In recent years, poultry diets have increasingly included biologically active additives with a pronounced positive effect on the viability and productivity of poultry. In this regard, the purpose of our study was to study the effectiveness of the use of complex preventive measures for experimental combined T-2 and aflatoxicosis in broiler chickens, taking into account the clinical, hematological status and organ weight. Broiler chickens were divided into 4 groups: birds of the first group (biological control) received only complete feed that did not contain mycotoxins; the second group served as a toxic control (feed was contaminated with a mixture of mycotoxins); the third group received a basic diet contaminated with a mixture of mycotoxins with the addition of complex agent No. 1 (plant glucans, hepatoprotector, vitamins E and C, immunostimulant); the fourth group is the main diet, contaminated with a mixture of mycotoxins with the addition of complex agent No. 2 (natural mineral bentonite, succinic acid, immunostimulant, vitamin A, probiotic based on bifidobacteria and lactobacilli). The duration of administration of toxins and prophylactic agents is 21 days. Complex agents were administered at a dose of 0.25% of the diet. As a result of the use of these agents, a decrease in the toxic load on the body was noted, which was manifested by an improvement in the clinical condition of chickens and normalization of morphological blood parameters. These results suggest that the complexes can be an effective means for reducing the toxic effects of mycotoxins on the body of broiler chickens with combined mycotoxicoses.