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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ivm</journal-id><journal-title-group><journal-title xml:lang="ru">Международный вестник ветеринарии</journal-title><trans-title-group xml:lang="en"><trans-title>International Journal of Veterinary Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-2419</issn><publisher><publisher-name>SpbGUVM Publishing House</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52419/issn2072-2419.2025.1.287</article-id><article-id custom-type="elpub" pub-id-type="custom">ivm-1645</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БИОХИМИЯ, МОРФОЛОГИЯ, ФИЗИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BIOCHEMISTRY, ANATOMY, PHYSIOLOGY</subject></subj-group></article-categories><title-group><article-title>Исследование биохимических показателей радужной форели на фоне применения пробиотических препаратов</article-title><trans-title-group xml:lang="en"><trans-title>Investigation of biochemical parameters of rainbow trout against the background of the use of probiotic drugs</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2781-5993</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпенко</surname><given-names>Л. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpenko</surname><given-names>L. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпенко Л.Ю. – д-р биол. наук, проф., зав. каф. биохимии и физиологии</p></bio><bio xml:lang="en"><p>Karpenko L.Yu. - Doctor of Biological Sciences, Professor, Head of the  Department of Biochemistry and Physiology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9659-9235</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сидорова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sidorova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сидорова Н.А.  – канд. биол. наук, доц., доц. каф. зоологии и экологии</p></bio><bio xml:lang="en"><p>Sidorova N.A. – Candidate of Sciences. Biol. sciences, assoc., assoc. Department of Zoology and Ecology</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5193-2487</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бахта</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bakhta</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бахта А.А. – канд. биол. наук, доц., доц. каф. биохимии и физиологии </p></bio><bio xml:lang="en"><p>Bakhta A.A. - PhD in Biology, Assoc. Prof., Assoc. Prof. of the Department of Biochemistry and Physiology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-5202-8857</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савушкин</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Savushkin</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Савушкин А.И. – науч. сотр.</p></bio><bio xml:lang="en"><p>Savushkin A.I.  – scientific. comp. </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1977-0913</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полистовская</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Polistovskaya</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Полистовская П.А. – канд. биол. наук, доц. каф.биохимии и физиологии </p></bio><bio xml:lang="en"><p>Polistovskaya P.A. – Ph.D. in Biology, Assoc. Prof. of the Department of  Biochemistry and Physiology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9495-0178</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никонов</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikonov</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никонов И.Н.  – канд. биол. наук, ст. преподаватель кафедры биохимии и физиологии </p></bio><bio xml:lang="en"><p>Nikonov I.N.  – Ph.D. in Biology, Senior Lecturer of the Department of Biochemistry and Physiology</p></bio><email xlink:type="simple">ilnikonov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5373-4794</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балыкина</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Balykina</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Балыкина А.Б. – канд. ветеринар. наук, доц. каф. биохимии и физиологии </p></bio><bio xml:lang="en"><p>Balykina A.B. – Ph.D. in Veterinary Sciences, Assoc. Prof. of the Department ofBiochemistry and Physiology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Санкт-Петербургский государственный университет ветеринарной медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State University of Veterinary Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Петрозаводский государственный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Petrozavodsk State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>03</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>287</fpage><lpage>293</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карпенко Л.Ю., Сидорова Н.А., Бахта А.А., Савушкин А.И., Полистовская П.А., Никонов И.Н., Балыкина А.Б., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Карпенко Л.Ю., Сидорова Н.А., Бахта А.А., Савушкин А.И., Полистовская П.А., Никонов И.Н., Балыкина А.Б.</copyright-holder><copyright-holder xml:lang="en">Karpenko L.Y., Sidorova N.A., Bakhta A.A., Savushkin A.I., Polistovskaya P.A., Nikonov I.N., Balykina A.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vetjournal.spbguvm.ru/jour/article/view/1645">https://vetjournal.spbguvm.ru/jour/article/view/1645</self-uri><abstract><p>В высокопродуктивном рыбоводстве, до сих пор, единственным способом профилактики и лечения инфекционных заболеваний служат антибиотики. Применение антибиотиков не всегда рационально, часто сопровождается формированием у патогенов множественной лекарственной устойчивости, сказывается на экологическом состоянии водоёма и безопасности выращиваемой рыбной продукции для человека. Многие антибактериальные препараты аккумулируются в отдельных органах и тканях и остаются стабильными даже после кулинарной обработки рыбы. В настоящее время, необходимость в препаратах с адаптогенными свойствами можно связать с изменением ситуации на рынке кормовых добавок, нехваткой отечественных эффективных нутрицевтиков и биологически активных веществ, включая витамины, минеральные комплексы, пищевые волокна, про- и пребиотики. Целью исследования являлось изучение влияния на биохимический статус организма радужной форели (Oncorhynchus mykiss) применения в ее рационе различных пробиотических добавок. Биохимические показатели крови (активность АлАТ, АсАТ, ЩФ, концентрацию общего билирубина, общего белка, альбуминов, креатинина, мочевины, глюкозы, холестерина) определялись на автоматическом биохимическом анализаторе Chem Well (Awareness Technology, США). В ходе исследований выявлено, что изучаемые пробиотические препараты не обладает гепатотоксичным и нефротоксичным эффектом, на что указывает отсутствие достоверных изменений биохимических показателей, характеризующих работу печени и почек, а оказывают положительное влияние на белковый обмен рыбы. Таким образом, можно сделать заключение о положительном действии экспериментальных пробиотических препаратов на основе штаммов бактерий р. Lactobacillus на метаболизм радужной форели. Полученные результаты выполненных исследований так же могут быть использованы для оптимизации состава продукционных комбикормов для радужной форели.</p></abstract><trans-abstract xml:lang="en"><p>In highly productive fish farming, antibiotics are still the only way to prevent and treat infectious diseases. The use of antibiotics is not always rational, often accompanied by the formation of multiple drug resistance in pathogens, affects the ecological state of the reservoir and the safety of farmed fish products for humans. Many antibacterial drugs accumulate in individual organs and tissues and remain stable even after cooking the fish. Currently, the need for drugs with adaptogenic properties can be associated with changes in the situation on the feed additives market, a shortage of domestic effective nutraceuticals and biologically active substances, including vitamins, mineral complexes, dietary fiber, pro- and prebiotics. The aim of the study was to study the effect of various probiotic supplements in the diet of rainbow trout (Oncorhynchus mykiss) on the biochemical status of its body. Blood biochemical parameters (ALT, AST, ALP activity, total bilirubin, total protein, albumin, creatinine, urea, glucose, cholesterol) were determined using an automatic Chem Well biochemical analyzer (Awareness Technology, USA). The studies revealed that the studied probiotic preparations do not have a hepatotoxic and nephrotoxic effect, as indicated by the absence of reliable changes in biochemical parameters characterizing the functioning of the liver and kidneys, but have a positive effect on the protein metabolism of fish. Thus, we can conclude that the experimental probiotic preparations based on strains of bacteria of the genus Lactobacillus have a positive effect on the metabolism of rainbow trout. The results of the studies can also be used to optimize the composition of production feed for rainbow trout.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>форель радужная</kwd><kwd>аквакультура</kwd><kwd>рыбное хозяйство</kwd><kwd>физиологический статус</kwd><kwd>биохимические показатели</kwd><kwd>кормовые добавки</kwd><kwd>пробиотики</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Rainbow trout</kwd><kwd>aquaculture</kwd><kwd>fish farming</kwd><kwd>physiological status</kwd><kwd>biochemical indicators</kwd><kwd>feed additives</kwd><kwd>probiotics</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">исследование выполнено при поддержке гранта российского научного фонда № 322-23 (Соглашение № 23-16-20026), проводимого совместно с Республикой Карелия с финансированием из Фонда венчурных инвестиций Республики Карелия (ФВИ РК).</funding-statement><funding-statement xml:lang="en">The study was supported by grant No. 322-23 of the Russian Science Foundation (Agreement No. 23-16-20026), conducted jointly with the Republic of Karelia with funding from the Venture Investment Fund of the Republic of Karelia (VIF RK).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Анализ возрастной динамики морфологических показателей крови форели радужной в условиях аквакультуры / Л. 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