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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ivm</journal-id><journal-title-group><journal-title xml:lang="ru">Международный вестник ветеринарии</journal-title><trans-title-group xml:lang="en"><trans-title>International Journal of Veterinary Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-2419</issn><publisher><publisher-name>SpbGUVM Publishing House</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.52419/issn2072-2419.2025.3.385</article-id><article-id custom-type="elpub" pub-id-type="custom">ivm-1833</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БИОХИМИЯ, МОРФОЛОГИЯ, ФИЗИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BIOCHEMISTRY, ANATOMY, PHYSIOLOGY</subject></subj-group></article-categories><title-group><article-title>Физиолого-биохимические аспекты применения Хитозана в ветеринарии</article-title><trans-title-group xml:lang="en"><trans-title>Physiological and biochemical aspects of Chitosan application in veterinary medicine</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5373-4794</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балыкина</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Balykina</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. ветеринар. наук, доц. </p></bio><bio xml:lang="en"><p>PhD of Veterinary Sciences, Assoc. Prof.</p></bio><email xlink:type="simple">andreeva-a-83@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2781-5993</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпенко</surname><given-names>Л. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpenko</surname><given-names>L. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р биол. наук, проф., зав. каф. биохимии и физиологии</p></bio><bio xml:lang="en"><p>D.Biol.sc. Professor </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-2884-9630</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киянчук</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiyanchuk</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>асс. каф. биохимии и физиологии</p></bio><bio xml:lang="en"><p>assistant of the Department of Biochemistry and Physiology</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9495-0178</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никонов</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikonov</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. биол. наук, ст. науч. сотр. </p></bio><bio xml:lang="en"><p>Cand.biol.sc. </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Санкт-Петербургский государственный университет ветеринарной медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State University of Veterinary Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>07</day><month>01</month><year>2026</year></pub-date><volume>0</volume><issue>3</issue><fpage>385</fpage><lpage>396</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Балыкина А.Б., Карпенко Л.Ю., Киянчук М.В., Никонов И.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Балыкина А.Б., Карпенко Л.Ю., Киянчук М.В., Никонов И.Н.</copyright-holder><copyright-holder xml:lang="en">Balykina A.B., Karpenko L.Y., Kiyanchuk M.V., Nikonov I.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vetjournal.spbguvm.ru/jour/article/view/1833">https://vetjournal.spbguvm.ru/jour/article/view/1833</self-uri><abstract><p>Хитозан обладает рядом характеристик, которые делают его актуальным для применения в ветеринарии. Он обладает антибактериальными и противогрибковыми свойствами, что делает его перспективным средством для терапии и профилактики инфекций у животных. Это особенно важно в условиях возрастающей резистентности бактерий к традиционным антибиотикам. Хитозан способствует ускорению процесса заживления ран за счет стимуляции пролиферации фибробластов и ангиогенеза. Это делает его ценным компонентом для ветеринарных перевязочных материалов и мазей. Привлекательным является тот факт, что хитозан может стимулировать иммунную систему животных, что ассоциировано с повышением сопротивляемости различным инфекционным заболеваниям. Данный полисахарид может использоваться в качестве добавки к кормам для животных, способствуя улучшению пищеварения и абсорбции питательных веществ, а также снижению уровня холестерина и триглицеридов. Согласно ряду исследований хитозан и гели на его основе не обладают токсичностью. Добавление 3 л 15% раствора комплексной синергетической пребиотической добавки на 1 т кисломолочной продукции за счет бактериостатических свойств хитозана позволяет в 2–2,5 раза увеличить сроки хранения, сохранив при этом живыми кисломолочные бактерии, сама же продукция при этом приобретает лечебно-профилактические свойства. Анализ с использованием баз данных РИНЦ, Scopus, Web of Science, Library Genesis, Google Scholar, Cyberleninka показал, что хитозан является перспективным для использования в животноводстве с целью улучшения молочной и мясной продуктивности. Несмотря на обширные данные о многочисленных преимуществах хитозана, недостаточно данных о вероятных побочных эффектах. Ограниченны так же данные о сочетанном применении хитозана с другими препаратами. Вышесказанное свидетельствует о необходимости проведения дальнейших исследований.</p></abstract><trans-abstract xml:lang="en"><p>Chitosan has a number of characteristics that make it relevant for use in veterinary medicine. It has antibacterial and antifungal properties, which makes it a promising tool for the treatment and prevention of infections in animals. This is especially important in conditions of increasing bacterial resistance to traditional antibiotics. Chitosan accelerates the wound healing process by stimulating fibroblast proliferation and angiogenesis. This makes it a valuable component for veterinary dressings and ointments. It is attractive that chitosan can stimulate the immune system of animals, which is associated with increased resistance to various infectious diseases. This polysaccharide can be used as an additive to animal feed, contributing to improved digestion and absorption of nutrients, as well as lowering cholesterol and triglycerides. According to a number of studies, chitosan and gels based on it are not toxic. Despite the extensive data on the numerous benefits of chitosan, there is insufficient data on potential side effects. There is also limited data on the combined use of chitosan with other drugs. The above indicates the need for further research.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>хитозан</kwd><kwd>мясная продуктивность</kwd><kwd>молочная продуктивность</kwd><kwd>иммунный статус</kwd></kwd-group><kwd-group xml:lang="en"><kwd>overview</kwd><kwd>chitosan</kwd><kwd>meat productivity</kwd><kwd>dairy productivity</kwd><kwd>immune status</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при поддержке гранта российского научного фонда № 25-26-00175 Молекулярно-генетические механизмы формирования иммунитета и микробиома рубца у молодняка крупного рогатого скота под влиянием хитозана(https://grant.rscf.ru/site/user/bids?role=master).</funding-statement><funding-statement xml:lang="en">The work was carried out within the framework of the Russian Science Foundation grant 25-26-00175 Molecular genetic mechanisms of immunity formation and the rumen microbiome in young cattle under the influence of chitosan. 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