In recent decades, hoof diseases have continued to cause significant damage to dairy cattle breeding. The most important condition for increasing the productivity and longevity of cows in dairy cattle breeding is effective prevention of hoof diseases and their timely treatment at the very beginning of the disease. A new drug, Fuzogel, has been developed at the Federal Center for Traumatology and Radiology of the Russian Academy of Sciences. The aim of the work was to evaluate the effectiveness of the new import-substituting drug, Fuzogel, in the form of a gel based on the active substances of copper and zinc metal complex compounds, in hoof diseases in cows. The gel form creates a mechanical barrier that prevents the development of infection by reducing the adhesion of vegetative and spore forms of bacteria and fungi to the tissues of the fingers and hooves. Tests of the effectiveness of this product in infectious and non -infectious hoof diseases in cows conducted in two agricultural enterprises indicate its high antimicrobial and anti-inflammatory activity in the initial and moderate severity of hoof lesions, rapid relief of the inflammatory response in such clinical manifestations of diseases as: digital dermatitis, ulcer of the pulp, coronary band, interdigital space vault, pododermatitis. "Fusogel", which does not contain antibiotics, can be used without restrictions on dairy cattle, which allows obtaining high-quality products (milk, meat, offal). After the use of "Fusogel" in cows with mild and moderate severity of the disease, previously detected vegetative forms of bacteria and microscopic fungi were completely absent, which positively affected the regenerative processes and restoration of hoof functions in cows. The high effectiveness of the drug allows its wide implementation in the system of measures to combat hoof diseases in cattle.