ivmМеждународный вестник ветеринарииInternational Journal of Veterinary Medicine2072-2419SpbGUVM Publishing House10.52419/issn2072-2419.2025.4.619ivm-1930Research ArticleНЕЗАРАЗНЫЕ БОЛЕЗНИNON-COMMUNICABLE DISEASEПерспективы применения клеточной терапии в ветеринарииProspects of cell therapy application in veterinary medicinehttps://orcid.org/0000-0002-1929-6345ГоловинС. Н.GolovinS. N.

науч. сотр. 

Researcher

labbibez@yandex.ruhttps://orcid.org/0000-0003-4703-1616КириченкоЕ. Ю.KirichenkoE. Yu.

д-р биол. наук. зав. каф. «Биоинженерия» 

Doctor of Biological Sciences, Head of the Department of Bioengineering

https://orcid.org/0000-0003-1194-7251СедоваД. А.SedovaD. A.

науч. сотр.

Researcher

https://orcid.org/0000-0002-9834-3989ЕрмаковА. М.ErmakovA. M.

д-р биол. наук, проф., директор Института живых  систем 

Doctor of Biological Sciences, Professor, Head of the Institute of Living Systems

НИЛ «МедЦифра»Россия«MedCifr» Research LaboratoryRussian FederationФГБОУ ВО «Донской государственный технический университет»РоссияDon State Technical UniversityRussian Federation20253012202504619636Copyright © Головин С.Н., Кириченко Е.Ю., Седова Д.А., Ермаков А.М., 20252025Головин С.Н., Кириченко Е.Ю., Седова Д.А., Ермаков А.М.Golovin S.N., Kirichenko E.Y., Sedova D.A., Ermakov A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vetjournal.spbguvm.ru/jour/article/view/1930

Концепция клеточной терапии основана на введении в организм эукариориотических клеток с целью лечения патологических состояний. Изначально возникшая в области медицины человека, клеточная терапия в ветеринарии находит все большее применение и активно развивается. В данном исследовании проанализированы и обобщены данные о применении клеточной терапии в ветеринарии, проведен обзор клинических исследований и нормативных документов. Целью нашего исследования было оценить перспективы применения терапии стволовыми клетками в ветеринарии, и основные направления клинических исследований, оценить их эффективность и определить основные критические моменты в практической реализации. Нами было установлено, что наибольшее количество исследований посвящено эффективности мезенхимных стволовых клеток в лечении остеоартроза у лошадей, спинальных травм у собак и кошек, острых и хронических повреждений кожи у собак. Основными направлениями применения клеточной терапии в ветеринарии является лечение хронических заболеваний суставов, острых и хронических повреждений спинного мозга и кожи. В обзоре представлены наиболее значимые достижения в области клеточной терапии мезенхимными стволовыми клетками в ветеринарии, а также обсуждаются проблемы контроля качества и правового регулирования в этой области. Несмотря на значительный прогресс в последнее время, ветеринарная регенеративная медицина находится только на начальном этапе развития, хотя есть все предпосылки для скорого внедрения ее в рутинную клиническую практику. Клеточная терапия позволит эффективно восполнять дефекты различных тканей, избежать высокоинвазивных вмешательств и значительно сократить сроки выздоровления. Создание аналогичных доступных препаратов является перспективной задачей для ветеринарии в России, а реализация подхода «Единое здоровье» будет способствовать эффективному развитию отрасли.

The concept of cell therapy is founded on the administration of eukaryotic cells into the organism to treat pathological conditions. While initially developed in human medicine, cell therapy is gaining increasing relevance and is actively evolving within veterinary practice. This study analyzes and summarizes current data on the application of cell therapy in veterinary medicine, providing a comprehensive review of clinical trials and regulatory documents. The objective of our research was to evaluate the prospects for stem cell therapy in veterinary medicine, identify primary areas of clinical investigation, assess therapeutic efficacy, and determine key critical factors affecting practical implementation. Our findings indicate that the majority of studies focus on the effectiveness of mesenchymal stem cells in treating osteoarthritis in horses, spinal injuries in dogs and cats, and both acute and chronic skin injuries in dogs. The principal directions for applying cell therapy in veterinary medicine include the treatment of chronic joint diseases, acute and chronic spinal cord injuries, and skin disorders. This review highlights the most significant advancements in mesenchymal stem cell therapy for veterinary applications and discusses challenges related to quality control and legal regulation in the field. Despite significant recent progress, veterinary regenerative medicine is still in its infancy, although there are all the prerequisites for its rapid introduction into routine clinical practice. Cell therapy will effectively repair defects in various tissues, avoid highly invasive procedures, and significantly reduce recovery times. The development of similar, affordable drugs is a promising goal for veterinary medicine in Russia, and the implementation of the "One Health" approach will facilitate the effective development of the industry.

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The authors declare that there are no conflicts of interest present.