Losses, associated with the massive spread of parasitic diseases, influence greatly the possible progressive growth in the number of hunting species of wild an-imals. The article provides an assessment of the epizootic situation of parasitoses of wild cloven-hoofed animals ( species Deers ) of the hornbeam-oak-dark forests sub-zone of Belarus. The comparative efficacy of anthelmintics of a wide spectrum of ac-tion, possessing immunomodulatory activity, is given. Ecological and parasitological studies of wild cloven-hoofed animals were car-ried out (2015-2018) in hunting farms of 9 territorial districts of the central forest-growing subzone, where the highest density of animals was recorded by the route method, as well as at stations - GLHU "Berezinsky forestry", GLHU "Ivatsevichy forestry ", Roga-chevskaya, Uzdenskaya and Minskaya ROS RGOO" BOOR " In total, samples of organs and tissues from 55 shot animals were studied, us-ing methods of excrement samples, generally accepted in parasitology. During the statistical processing of the collected material in order to assess the infestation of an-imals by parasites, the following indicators were used: the extent of invasion (EI) and the intensity of invasion (II). Experiments have shown that the class of nematodes is the most species-rich in the helminthoses of wild artiodactyl animals. Widespread helminthiases in elk and red deer are - mecystocirrhosis and strongyloi-dosis, and in European roe deer - tri-chostrongyloidosis. The focus of helminthic infestation in elk should be considered pine young stands, complex spruce forests, renewable felling, for red deer - a complex pine for-est, a complex spruce forest, and for European roe -broad-leaved plantations, black alder forests and agricultural fields. For deworming of wild animals high antiparasitic efficiency was shown by new complex remedies - "Polyparatsid" and "Tetrahelminthicide", which have an im-munostimulating effect.