In the structure of diseases of cattle, the leading place is occupied by obstetric and gynecological diseases, which are most often manifested in the postpartum period. Metritis is one of the most common, which occurs in 50-70%, and in some highly productive herds occurs in 90% of new-bodied cows. The article presents data describing the different course of clinical manifestations of postpartum metritis in dairy cows. Different variants of its manifestation are shown. The diagnosis was established in accordance with the guidelines for the prevention of infertility in highly productive dairy cattle. All animals were subjected to daily thermometry for 10 days after calving. First group - mild course (n=20) was subjected to complex treatment: myotropic - injections of 2% synestrol oil solution at a dose of 0.6 ml/100 kg of body weight on days 1 and 2 and oxytocin at a dose of 10 U/100 kg of body weight for days 2 to 5; generally stimulating -three time administration of placenta denatured emulsified (PDE) on days 1, 5 and 9 subcutaneously at a dose of 5 ml/100 kg of body weight, 15% ASD-2F solution on trivitamin, intramuscularly at a dose of 10 ml/animal in 1, 3 and 5 days of treatment) ; ethiotropic agents - suspension "Nioxitil" intrauterine at a dose of 15 ml/100 kg of body weight with a 48-hour interval until clinical recovery. It was found that in cows with a mild course, the therapeutic effectiveness was higher - by 5.1 -15.5%, with a decrease in the number of intrauterine injections - by 201-3.9,days of treatment - by 2.2-5.7. Indicators of further reproductive capacity indicate a decrease in the insemination index-by 0.4-0.9, days after calving, before fertilization-by 12.527.8.