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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ivm</journal-id><journal-title-group><journal-title xml:lang="ru">Международный вестник ветеринарии</journal-title><trans-title-group xml:lang="en"><trans-title>International Journal of Veterinary Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-2419</issn><publisher><publisher-name>SpbGUVM Publishing House</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ivm-437</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>БИОХИМИЯ, АНАТОМИЯ, ФИЗИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BIOCHEMISTRY, ANATOMY, PHYSIOLOGY</subject></subj-group></article-categories><title-group><article-title>Способ нормализации энергетического метаболизма коров в послеотельный период</article-title><trans-title-group xml:lang="en"><trans-title>The method of normalizing the energy metabolism of cows in the postacute period</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бондаренко</surname><given-names>Ф. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bondarenko</surname><given-names>F. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лобода</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Loboda</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малков</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Malkov</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малков</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Malkov</surname><given-names>M. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данькова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dankova</surname><given-names>T. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитин</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitin</surname><given-names>A. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>СПБГТИ(ТУ)</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ООО «НПФ «ЭЛЕСТ»</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>ЗАО Племенной завод «Гомонтово»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>02</day><month>06</month><year>2021</year></pub-date><volume>0</volume><issue>1</issue><fpage>88</fpage><lpage>92</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бондаренко Ф.В., Лобода А.С., Малков Н.В., Малков М.А., Данькова Т.В., Никитин А.М., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Бондаренко Ф.В., Лобода А.С., Малков Н.В., Малков М.А., Данькова Т.В., Никитин А.М.</copyright-holder><copyright-holder xml:lang="en">Bondarenko F.V., Loboda A.S., Malkov N.V., Malkov M.A., Dankova T.V., Nikitin A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vetjournal.spbguvm.ru/jour/article/view/437">https://vetjournal.spbguvm.ru/jour/article/view/437</self-uri><abstract><p>Целью проведенной работы являлось изучение возможности нормализации энергетического метаболизма коров в послеотельный период новым способом, через усиление глюконеогенеза и восстановление нормального функционирования цикла трикарбоновых кислот. Для реализации способа было предложено ввести в рацион коров в форме смеси-регулятора энергетического метаболизма такие субстраты глюконеогенеза как пируват, фосфоенолпируват и остальные вещества находящиеся на пути образования глюкозы, а также субстанции стимулирующие пополнение пула ключевого компонента цикла трикарбоновых кислот, оксалоацетата, а именно ко-факторы ферментов метилмалонилКоАмутазы и карбоксилазы пирувата, и глюкогенные аминокислоты. Для испытания способа смесь скармливали опытным животным в составе общего смешанного рациона в дозировке 250 г/гол/сут. в период от отела до 30 суток лактации. За шесть месяцев испытаний на племенном заводе «Гомонтово» в исследовании приняли участие 700 новотельных коров. Для оценки эффективности способа нормализации энергетического метаболизма анализировали частоту проявления случаев болезней связанных с нарушением метаболизма. В качестве контроля использовали статистические данные по новотельным коровам полученные в 2017 году, до начала испытания регулятора энергетического метаболизма. В результате проведенных испытаний было показано, что применение способа позволило снизить количество случаев возникновения кетоза в среднем на 55%, количество случаев смещения сычуга на 70%, и число случаев тяжелого расстройства пищеварения на 53%. По результатам проведенных испытаний регулятор энергетического метаболизма был включен в схему кормления КРС племенного завода «Гомонтово» на постоянной основе.</p></abstract><trans-abstract xml:lang="en"><p>The aim of presented work was to investigate whether energetic metabolism of cow in the after calving period could be normalized by using new approach which provides stimulation of gluconeogenesis and optimal functioning of citric acid cycle. For realization of the approach it was proposed to introduceinto ration of cows, in the form of mixture-stimulator of energetic metabolism, such gluconeogenesis substrates as pyruvate, phosphoenolpyruvate and all other compounds present on the way of glucose synthesis and also number of compounds known to stimulate synthesis of main citric acid cycle component- oxaloacetate namely methylmalonyl-CoA mutase and pyruvate carboxylase co-factors and glycogenic amino acids. To test the approach, mixture was fed to the animals in experimental group in the composition of total mixed ration in the dose of 250 g/head/day starting after calving and up to 30 days of lactation. Within six month of trials on the basis of «Gomontovo» farm 700 cows have participated in the experi ment. To estimate approach efficiency number of cases of diseases associated with metabolic disorders was analyzed. Statistical data obtained before beginning of described trials in 2017 for after-calving cows was used as control. As a result of performed research it was shown that application of provided approach leads to the decrease of ketosis cases on 55%, abomasum displacement on 70% and hard digestion disorders on 53%. In accordance with obtained results mixture-stimulator of energetic metabolism was introduced to the feeding schedule of «Gomontovo» farm in the permanent manner.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>молочный скот</kwd><kwd>метаболизм</kwd><kwd>болезни крупного рогатого скота</kwd><kwd>глюконеогенез</kwd><kwd>dairy cattle</kwd><kwd>metabolism</kwd><kwd>productivity diseases</kwd><kwd>gluconeogenesis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ametaj N.B. 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