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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ivm</journal-id><journal-title-group><journal-title xml:lang="ru">Международный вестник ветеринарии</journal-title><trans-title-group xml:lang="en"><trans-title>International Journal of Veterinary Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-2419</issn><publisher><publisher-name>SpbGUVM Publishing House</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">ivm-445</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНАЯ ФАРМАКОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>Использование морских свинок в биомедицинских исследованиях</article-title><trans-title-group xml:lang="en"><trans-title>Using guinea pigs for biomedical research</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рыбакова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rybakova</surname><given-names>A. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макарова</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarova</surname><given-names>M. .</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>АО «НПО «Дом фармации»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>02</day><month>06</month><year>2021</year></pub-date><volume>0</volume><issue>1</issue><fpage>132</fpage><lpage>137</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Рыбакова А.В., Макарова М.Н., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Рыбакова А.В., Макарова М.Н.</copyright-holder><copyright-holder xml:lang="en">Rybakova A..., Makarova M...</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vetjournal.spbguvm.ru/jour/article/view/445">https://vetjournal.spbguvm.ru/jour/article/view/445</self-uri><abstract><p>Морская свинка (Cavia porcellus) принадлежит к отряду грызунов, семейству свинковых (Cawiidae). Впервые морские свинки были одомашнены в Южной Америке, затем были распространены по всему миру в качестве домашних питомцев. Начиная с 18-го века свинки стали широко использоваться для научных исследований различных направлений. В наши дни морская свинка используется в качестве модели для многих инфекционных заболеваний человека, включая легочные, половые, глазные, слуховые, желудочно-кишечные и другие инфекции, которые могут угрожать жизни людей и животных. Преимущество использования морских свинок, как тест-системы среди ряда других лабораторных животных заключается в их сходстве с людьми внешними признаками проявления той или иной патологии и развитию иммунного ответа. Морские свинки часто используются в исследованиях по оценке репродуктивной токсичности, контактной гиперчувствительности или дерматита. Особенности строения дыхательных путей морской свинки делают этих животных хорошей моделью для изучения респираторных заболеваний. Функционально дыхательные пути морской свинки достаточно реактивны для некоторых вдыхаемых соединений. Морские свинки могут быть альтернативой хорькам при моделировании инфекционных заболеваний. Выбор правильной биологической тест системы для исследования является залогом получения качественных и достоверных результатов уже на начальных этапах. В свою очередь видовое разнообразие при проведении доклинических исследований дает возможность исследователю подобрать адекватную модель для изучения той или иной патологии.</p></abstract><trans-abstract xml:lang="en"><p>Guinea pig (Cavia porcellus) belongs to the detachment of rodents, the family of guinea pigs (Cawiidae). For the first time guinea pigs were domesticated in South America, then were distributed around the world as pets. Since the 18th century, pigs have become widely used for scientific research in various fields. Today, guinea pig is used as a model for many human infectious diseases, including pulmonary, genital, ocular, auditory, gastrointestinal and other infections that can threaten the lives of people and animals. The advantage of using guinea pigs as a test system among a number of other laboratory animals is their similarity with humans to external signs of manifestation of one or another pathology and the development of an immune response. Guinea pigs are often used in studies evaluating reproductive toxicity, contact hypersensitivity or dermatitis. The peculiarities of the structure of the respiratory tract of guinea pig make these animals a good model for studying respiratory diseases. Functionally, the respiratory tract of guinea pig is sufficiently reactive for some inhaled compounds. Guinea pigs can be an alternative to ferrets in the modeling of infectious diseases. Choosing the right biological test system for research is the key to obtaining quality and reliable results already at the initial stages. In turn, species diversity in preclinical studies enables the researcher to select an adequate model for studying a particular pathology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лабораторные животные</kwd><kwd>морские свинки</kwd><kwd>биомедицинские исследования</kwd><kwd>laboratory animals</kwd><kwd>guinea pigs</kwd><kwd>biomedical research</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бондарева, Е.Д. Зоотехнические характеристики содержания морских свинок в экспериментальных вивариях / Е.Д. Бондарева, А.В. Рыбакова, М.Н. Макарова // Международный вестник ветеринарии. -2017. -№3. -С. 108-115.</mixed-citation><mixed-citation xml:lang="en">Бондарева, Е.Д. 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