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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ivm</journal-id><journal-title-group><journal-title xml:lang="ru">Международный вестник ветеринарии</journal-title><trans-title-group xml:lang="en"><trans-title>International Journal of Veterinary Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2072-2419</issn><publisher><publisher-name>SpbGUVM Publishing House</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17238/issn2072-2419.2019.4.19</article-id><article-id custom-type="elpub" pub-id-type="custom">ivm-92</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИНВАЗИОННЫЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INVASIVE DISEASE</subject></subj-group></article-categories><title-group><article-title>Применение препарата «ИВЕРСАН» при гастрофилезе лошадей</article-title><trans-title-group xml:lang="en"><trans-title>Application of the drug «IVERSAN» for treatment gasterophilosis of horses</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5651-5976</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаврилова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gavrilova</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4473-1940</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белова</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Belova</surname><given-names>L. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логинова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Loginova</surname><given-names>O. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ситникова</surname><given-names>Р. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Sitnikova</surname><given-names>R. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Санкт-Петербургская государственная академия ветеринарной медицины»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State Academy of Veterinary Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>24</day><month>05</month><year>2021</year></pub-date><volume>0</volume><issue>4</issue><fpage>19</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гаврилова Н.А., Белова Л.М., Логинова О.А., Ситникова Р.С., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Гаврилова Н.А., Белова Л.М., Логинова О.А., Ситникова Р.С.</copyright-holder><copyright-holder xml:lang="en">Gavrilova N.A., Belova L.M., Loginova O.A., Sitnikova R.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vetjournal.spbguvm.ru/jour/article/view/92">https://vetjournal.spbguvm.ru/jour/article/view/92</self-uri><abstract><p>Для изучения терапевтического действия препарата «Иверсан», содержащего в 1,0 мл 40,0 мг ивермектина, применяемого орально при гастрофилезе лошадей были сформированы три группы из лошадей различных пород, весом от 200 до 600 кг в возрасте от 12 месяцев до 17 лет, у которых визуальным методом обнаружены яйца и личинки овода рода Gastrophilus. Животным из группы № 1 препарат в дозе 1 мл на 200 кг массы животного (200 мкг ивермектина на 1 кг массы животного) задавали индивидуально с водой из шприца по беззубому краю на корень языка. Лошадям в группе № 2 задавали препарат с кормом из расчета 1 мл препарата на 200 кг массы животного. Рассчитанную индивидуально дозу препарата смешивали с небольшим количеством овса (50-70 г) и скармливали лошадям индивидуально, однократно. Лошадям контрольной группы (№3) препарат не применяли. До введения препарата и через 10 дней после его применения у животных подопытных групп (№ 1, 2) брали кровь на гематологические и биохимические показатели. В течение 14 дней после применения препарата проводили осмотр слизистых оболочек ротовой полости лошадей. Установили, что препарат «Иверсан», содержащий в 1,0 мл 40,0 мг ивермектина, применяемый орально, однократно оказывает выраженное терапевтическое действие при гастрофиллезе лошадей. По результатам клинических и биохимических исследований крови животных сделан вывод об отсутствие негативного побочного действия препарата на организм лошадей.</p></abstract><trans-abstract xml:lang="en"><p>The purpose of the work was to study the grag Iversan, containing 40.0 mg of ivermectin in 1.0 ml against equine gasterophilosis. Three groups of naturally infested horses were formed. Animals were of various breeds, from 200 to 600 kg, from 12 months to 17 years. Eggs and larvae of Gasterophilus botfly were detected visually. Animals from Group 1 were given the solution at a dose of 1 ml per 200 kg of body weight (200 μg ivermectin per 1 kg of animal weight) individually, orally with water from a syringe along the margo interalveolaris on the base of tongue. Horses of Group 2 were given the drug with feed individually, once, in the same dose which was calculated individually and mixed with a small amount of oats (50-70 g). The horses of the control group (3) did not received the drug. Before the solution administration and 10 days after animals of experimental groups (1 and 2) were blood sampled. Within 14 days after the drug was used, oral cavity mucous membranes of horses had been examined. It was found that tested solution used orally, once, has a pronounced therapeutic effect against equine gasterophilosis. No itching, irritation or swelling of the skin and mucous membranes, no hyperemia and other signs of an allergic reaction of the organism were found. The drug had no side effects, which was confirmed by the results of clinical blood test and blood chemistry of animals.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лошади</kwd><kwd>гастрофилез</kwd><kwd>оральное применение</kwd><kwd>ивермектин 4%</kwd><kwd>horses</kwd><kwd>gastrofilosis</kwd><kwd>oral administration</kwd><kwd>ivermectin 4%</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Енгашев, С.В. Применение препарата Иверсан при гельминтозах лошадей / С.В. Енгашев, Е.С. Енгашева, Л.М. Белова, Н.А. Гаврилова, А.Н. Токарев, О.А. Логинова, Ю.Е. Кузнецов, М.С. Петрова, Е.В. Ермакова // ж. «Ветеринария». - 2018.- № 8.- С.42-46.</mixed-citation><mixed-citation xml:lang="en">Енгашев, С.В. Применение препарата Иверсан при гельминтозах лошадей / С.В. Енгашев, Е.С. Енгашева, Л.М. Белова, Н.А. Гаврилова, А.Н. Токарев, О.А. Логинова, Ю.Е. Кузнецов, М.С. Петрова, Е.В. 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