The effect of cyprofloxacin on the leukogramm of chickens blood with experimental colibacillosis

Abstract

The purpose of this work was to study the dynamics of indicators of the system of white blood of birds due to the use of the chemotherapeutic drug ciprofloxacin, which has a wide spectrum of effects. Ciprofloxacin has a more active effect on gram-negative bacteria, as well as on colibacillo-sis. For the study, three groups of chickens were formed (I - control, II and III - experienced), which consisted of male Haysex Brown cross-hares. Experimental infection of chickens of groups II and III with the culture of Escherichia coli was carried out. The day before and within four days after infection, chickens of group III received ciprofloxacin at a dose of 200 mg/l with water. Blood sampling from all experimental birds was performed on the day of infection, then at 1, 5, 10, 15 and 20 days after infection. White blood indices were studied: leukocyte count and leukocyte formula. As a result of the analysis of the obtained data, significant changes in some indicators of white blood in groups II and III relative to the control group were noted. The presence of an inflammatory reaction, characterized by a significant increase in the absolute and percentage of neutrophils, monocytes and basophils in groups II and III in comparison with the control. However, white blood counts in group III were relatively closer to those in the control group.