Correlation indicators between pharmacokinetic parameters of sorbitol in clinically healthy laboratory and farm animals

Abstract

The aim of this study was to conduct a comparative correlation analysis of the pharmacokinetic parameters of exogenous sorbitol in clinically healthy laboratory rats and cattle to assess the degree of similarity or difference in its elimination and distribution, which forms the basis for substantiating (or refuting) the possibility of creating cross-species diagnostic models. Correlation analysis is a key method in veterinary pharmacology, allowing for the evaluation of relationships between pharmacokinetic parameters and organ function in animals. This study examined the correlations between the pharmacokinetic parameters of exogenous sorbitol in clinically healthy laboratory rats and farm animals (cattle). Sorbitol plasma concentration, total plasma clearance, mean residence time, and volume of distribution were analyzed. Parametric (Pearson correlation coefficient) and nonparametric (Spearman rank correlation coefficient) methods were used for statistical analysis. The results showed no consistent correlations between species or between males and females, indicating significant interspecies and individual differences in sorbitol metabolism. These data highlight the need to consider species-specific characteristics when using sorbitol as a marker for assessing hepatobiliary function. Further research across a wider range of animal species is required to develop universal diagnostic models. Thus, this study makes a significant contribution to understanding the principles of species-specific pharmacokinetics and serves as an important caution against the simplistic cross-species transfer of diagnostic methods. Its findings provide the basis for a more balanced, differentiated, and, consequently, more effective approach to assessing hepatobiliary function in animals of various species in clinical and scientific veterinary practice.