The effect of the allokin-alpha immunostimulator on biochemical and immunological blood parameters of calves
https://doi.org/10.52419/issn2072-2419.2026.1.26
Abstract
Bronchopneumonia of calves associated with the immunological immaturity of the body, causes serious damage to industrial cattle breeding. Due to the increasing antibiotic resistance of bronchopneumonia pathogens, alternative treatment methods are becoming more relevant including immunostimulants in particular allokin-alpha, which mechanism of action is to switch the mechanism of the immune response from humoral to cellular. The aim of the study was to study the effect of the immunostimulator allokin-alpha on the biochemical and immunological parameters of the blood of calves with bronchopneumonia. The research conducted in the spring period in a breeding plant in the Leningrad region on calves of the Holstein breed at three months of age and on basis of the Department of Microbiology, Virology and Immunology of the Federal State Budgetary Educational Institution of Higher Education. Total protein, albumin, globulin, urea, nitrogen, creatinine, bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, amylase, glucose, cholesterol, calcium, phosphorus and their ratios measured in the blood of calves. Among the immunological parameters, such parameters as bactericidal activity of blood serum, myeloperoxidase, lysosomal cationic proteins, and phagocytic activity evaluated. The use of an immunostimulatory accelerates the restoration of immune system functions. Thus, the level of myeloperoxidase remains elevated by only 27,7 % relative to the control, whereas in animals without an immunostimulator this indicator is 28,4 %. Phagocytic activity significantly increased by 30,4 %, but it was approaching normal values, unlike in the first group (55,4 % higher). When allokin-alpha is used in sick animals, there is a lower protein deficiency (the percentage of globulin content is close to the norm in healthy animals, 1,1 % higher), but liver damage persists (increased transaminases). These changes indicate a gradual recovery of the general condition of the body after the disease.
About the Authors
A. A. Sukhinin
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Doctor of Biology Sciences, Professor, Head of the Department microbiology, virology and immunology
N. A. Stepanova
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
postgraduate student of the Department microbiology, virology and immunology
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Review
For citations:
Sukhinin A.A., Stepanova N.A. The effect of the allokin-alpha immunostimulator on biochemical and immunological blood parameters of calves. International Journal of Veterinary Medicine. 2026;(1):26-37. (In Russ.) https://doi.org/10.52419/issn2072-2419.2026.1.26
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