Estimation of the activity of horse neutrophyl during dehelminization with a preparation from the group of macrocyclic lactons on the background of a probiotic

Abstract

The aim of the work was to study the dynamics, indicators of phagocytic activity of peripheral blood neutrophils of horses during deworming with a drug from the group of macrocyclic lactones against the background of the use of a new domestic probiotic "Bioxymin horse". In all animals participating in the experiment, a decrease in natural resistance was found, characterized by a decrease in the ability of blood neutrophils to absorb foreign material. In the group of horses that served as an indicator of invasion, fluctuations in the parameters of the phagocytic index and phagocytic activity were noted, the PI on the 7th day of the experiment increased from 5.9 bw. to 8.4 m.t., then a slow decline and by the 45th day the PI is equal to 6.8 m.t., while by the seventh day of the experiment, the FA decreases from 44.0% to 40.8%, by the 15th day a sharp rise in values to 51.0%, by the 45th day the growth continued to 52.0%. The absorption capacity changed cyclically. We associate such dynamics with a change in the intensity of invasion over the course of the experiment and the emerging allergic (sensibilizing) reaction of the horse's body. In the horses of the experimental groups, on the 7th day of the experiment, an increase in phagocytic activity was noted by 15.4% and 35.8%, respectively, according to groups, the revealed difference was statistically significant (p˂0.05). Obviously, this indicates the activation of the cellular defense link under the influence of the probiotic preparation. Based on the data obtained, it can be concluded that helminthic invasion and the use of anthelmintics from the group of macrocyclic lactones without additional immunostimulants have a depressive effect on the cellular link of natural immunity. The probiotic preparation Bioxymin horse has a positive effect on the horse's cellular immunity.