Physiological and biochemical status in laboratory animals during the administration of clatrate complex 20-hydroxiekdisone with arabinogalactan

Abstract

Ecdysteroids are a group of polyhydroxylated steroid compounds, which are one of the most widespread and numerous families of steroid compounds in the biosphere and possess a variety of biological activities: adaptogenic, anabolic, antitoxic, stress and organoprotective, antidiabetic, etc. For physiological studies, a lattice active clathrate complex (CC) of 20-hydroxyecdysterone (20 -HE) was created based on the synthesis of a supramolecular compound with arabinogalactan (AG) by clathration. The aim of the study was to assess the physiological status of the organism of Wistar rats after administration of CС 20-HE with AG. The experiments were carried out on 110 male and female rats. The rats were divided into 4 groups. Group I rats were injected with an aqueous solution of AG; Group II - CC 20- HE with AH at a dose of 1.0 mg / kg; Group III - CC 20-HE with AG at a dose of 5.0 mg / kg. It has been shown in rats that the administration of CC 20-HE with AG at doses of 1.0 and 5.0 mg / kg promotes the intensification of metabolism, in particular, lipid metabolism improves, and biosynthetic and bioenergetic processes in their bodies are enhanced. The increase in anabolic processes in the body of rats of the experimental groups is evidenced by data on an increased level of total protein and albumin, a higher activity of creatine kinase and alkaline phosphatase against a background of low concentrations of urea, triglycerides and cholesterol. In rats receiving CC 20-HE with AG, an increase in bioenergetic processes was noted towards the most effective aerobic phase of energy production in order to provide equivalents of an increasing energy-consuming protein-synthesizing system. It should be noted that the best results were obtained at a dose of 1.0 mg / kg of body weight in rats.