White blood parameters in cockerels under different doses of enrofloxacin in experimental salmonellosis conditions

Abstract

Due to insufficient data of antimicrobial agents influence on the physiological state of birds the study of the influence of Enrofloxacin in doses of 200 and 100 mg/l on white blood parameters at the roosters of the cross "Haysex Brown" (at the conditions of experimental infection with Salmonella infantis culture) was carried out. Four groups of roosters were involved in the experiment, I – a control group, II and III, received the drug in doses of 200 mg/l and 100 mg/l the day before and during the next three days: group IV was subjected to experimental infection without further treatment. Blood was taken from all groups on the 1st, 3rd, 5th, 7th and 9th day after infection. In the course of the study the number of leukocytes and leukogram was determined with the subsequent calculation of the leukocyte index, Krebs index and immunoresponsiveness index data. Significant statistically reliable changes in all groups in comparison with the control were registered throughout the whole experience, which indicates a low activity of the used doses of Enrofloxacin against the strain Salmonella infantis. An increase in the number of leukocytes in the blood of chicks of all experimental groups, as well as serious dynamic fluctuations in leukocyte indexes reflect the development of a strong infectious process in the chicks. The most highly reliable changes were found in the immunoreactivity index data, where the values of the experimental groups were several times lower relative to control. In addition, the use of enrofloxacin at a dose of 100 mg/l had some suppressive effect on the immune reactions in the chicks of the third group.