Microcirculatory bed and membrane digestion in newborn calves with dyspepsia

 The scientific article provides information about the study of the features of blood supply, the state of the microcirculatory bed in clinically healthy newborn calves, as well as in the case of their dyspepsia. It was found that in clinically healthy newborn calves, the microcirculatory bed of the conjunctiva of the eyeball is represented by all the links of microcirculation, namely: parallel arterioles and venules that end in the corresponding capillaries, they form a cellular structure on the conjunctiva. In calves with dyspepsia, there are marked changes in the microcirculation of certain areas of the  conjunctiva of the eyeball. In this case, microcirculatory disorders are characterized by a change in the shape of the vessels, the unevenness of their caliber, the appearance of ampouleshaped extensions along the course  of the vessels, the appearance of constrictions in them. The ratio of the diameter of the venules of the diameter of the arterioles is 1:4, and in healthy calves this ratio is 1:2.
Intravascular changes are characterized by the appearance of aggregation of red blood cells (sludge phenomenon) in most vessels of the venular bed, as well as in capillaries and isolated cases in arterioles. Against the background of  pronounced disorders in the microcirculatory bed, and as is known, they reflect a systemic circulatory disorder, we conducted parallel studies of membrane digestion, using the example of protein hydrolysis. It was found that in sick  calves, there was a decrease in the enzymatic activity of glycyl-L-leucine dipeptidase along the proximal gradient. Thus, in calves with dyspepsia, there is a disorder of blood circulation in general and in the digestive system in  particular, which is a determining factor in the occurrence of disorders of membrane digestion, which performs the intermediate and final stages of hydrolysis of nutrients. 

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