THE EFFECT OF ENROFLOXAVETFERON AND GENTABIFERON-B ON BLOOD PARAMETERS OF COWS IN THE TREATMENT OF ENDOMETRITIS
https://doi.org/10.52419/issn2072-2419.2024.4.152
Abstract
Impaired fertility in cattle is the cause of economic losses in livestock farms. Complex treatment of cows with acute endometritis may include various approaches, including the use of antibiotics and interferon-based drugs. The therapeutic approach associated with the use of immunostimulating substances is the safest. The aim of the study was to evaluate the blood parameters of cows during the treatment of acute postpartum catarrhal endometritis using «Enrofloxacinferon-B» and «GentabiferonB». It was found that therapy with «Enrofloxacinferon-B», «Gentabiferon-B», and the traditional treatment regimen led to an increase in phagocytic activity, which was probably due to the activation of the immune system of animals. At the same time, during therapy with «Enrofloxacinferon-B», a decrease in catalase activity was observed, which may be due to a decrease in the level of active oxygen forms in the blood of animals during therapy with this drug. It was also noted that during the therapy with «Enrofloxacinferon-B» no changes in the level of the circulating immune complexes were observed, while with the traditional treatment regimen an increase in this indicator was observed. Therapy with «Enrofloxacinferon-B» did not lead to an increase in neutrophils. At the same time, both the traditional treatment regimen and therapy with «Gentabiferon-B» led to an increase in the proportion of neutrophils. It is noteworthy that there was no pronounced negative effect on blood parameters of all three endometritis treatment options. It can be assumed that the most optimal treatment regimen for acute postpartum catarrhal endometritis in cows may be therapy including «Enrofloxacinferon-B» at a dose of 20 ml at intervals of 24 hours for 5 days.
About the Authors
M. Yu. Syromyatnikov
All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy;
Voronezh State University of Engineering Technology;
Voronezh State University
Russian Federation
Russian Federation
Syromyatnikov M.Yu. – PhD in Biological Sciences, Associate Professor, Leading Researcher
S. V. Shabunin
All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy
Russian Federation
Russian Federation
Shabunin S.V. – PhD in Veterinary Sciences, Professor, Academician of the Russian academy Of Sciences, Scientific Advisor of The All-Union Research Institute of Non-Contagious Animal Diseases
V. I. Mikhalev
All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy
Russian Federation
Russian Federation
Mikhalev V.I. – PhD in Veterinary Sciences, Сhief Researcher
E. A. Chirkin
Voronezh State University
Russian Federation
Russian Federation
Chirkin E. A. – student
E. V. Mikhaylov
All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy
Russian Federation
Russian Federation
Mikhaylov E.V. – PhD in Veterinary Sciences, Leading Researcher
References
1. Britt J.H. Invited review: learning from the future-a vision for dairy farms and cows in 2067 /J.H. Britt, R.A. Cushman, C.D. Dechow [et al.] // Journal of Dairy Science. 2018:101(5):3722-3741. ‒ DOI 10.3168/jds.2017-14025.
2. Sheldon I.M. Tolerance and innate immunity shape the development of postpartum uterine disease and the impact of endometritis in dairy cattle / I.M. Sheldon, J.G. Cronin, J.J. Bromfield // Annual Review of Animal Biosciences. 2019:7:361-384. ‒ DOI 10.1146/annurev-animal-020518-115227
3. Miranda-CasoLuengo R. Delayed differentiation of vaginal and uterine microbiomes in dairy cows developing postpartum endometritis / R. Miranda-CasoLuengo, J. Lu, E.J. Williams [et al.] // PLoS One. 2019:14 (1):e0200974 ‒ DOI 10.1371/journal.pone.0200974
4. Haimerl P. Invited review: Antibiotic treatment of metritis in dairy cows: a systematic approach / P. Haimerl, W. Heuwieser // Journal of Dairy Science. 2014:97 (11):6649-61. ‒ DOI 10.3168/jds.2014-8462.
5. Haimerl P. Therapy of bovine endometritis with prostaglandin F2α: a meta-analysis. / P. Haimerl, W. Heuwieser, S. Arlt // Journal of Dairy Science. 2013:96(5):2973-87. ‒ DOI 10.3168/jds.2012-6154.
6. Bolotova V. S. Complex method of treatment of cows with chronic endometritis. / V. S. Bolotova, V. I. Mikhalev, O. A. Manzhurina // Veterinary Pharmacological Bulletin. 2023:21(4):143-149. - DOI 10.17238/issn2541-8203.2023.3.143. 3 (In Russ).
7. Skorikov V. N. Use of bovine recombinant α- and γ-interferons for the prevention of acute postpartum endometritis in cows / V. N. Skorikov, V. I. Mikhalev // Veterinary Pharmacological Bulletin. 2019:6(1):69-72.– DOI 10.17238/issn2541-8203.2019.1.69 (In Russ).
8. Zaitseva AV Evaluation of a complex drug based on biochemical parameters of calf blood serum / AV Zaitseva, VA Prokulevich, GE Dremach [et al.] // Veterinary Journal of Belarus. 2016:2:13-17. (In Russ).
9. Gritsyuk V. Treatment of mastitis in cows with the complex drug Gentabiferon-B / V. Gritsyuk, G. Vostrorova, L. Cheskidova [et al.] // Veterinary science of agricultural animals. 2024:(1) (In Russ).
10. Shakhov A. G. Methodological recommendations for assessing and correcting the immune impact of animals / A. G. Shakhov [et al.] // New research methods on problems of veterinary medicine. Part III. "Research methods on problems of non-infectious nature in productive animals". - M.: RAAS, 2007:216-292. (In Russ).
11. Methods of veterinary clinical laboratory diagnostics / I. P. Kondrakhin, A. V. Arhipov, V. I. Levchenko [et al.]. - M.: Kolos, 2004:520. (In Russ).
12. Shakhov A. G. Methodological recommendations for assessing and correcting nonspecific resistance of animals / A. G. Shakhov Yu. N. Brigadirov, A. I. Anufriev [et al.]. – Voronezh, 2005:32. (In Russ).
13. Retsky M.I. Methodical provisions for the study of free-radical oxidation processes and antioxidant defense systems of the body / M.I. Retsky, S.V. Shabunin, G.N. Bliznetsova [et al] – Voronezh, 2010:61. (In Russ).
14. Grebneva O.L. Ability to calculate indicators of low and medium molecular weight of blood / O.L. Grebneva, E.A. Tkachuk, V.O. Chubeiko // Clinical laboratory diagnostics. 2006:(6):17-19 (In Russ).
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For citations:
Syromyatnikov M.Yu., Shabunin S.V., Mikhalev V.I., Chirkin E.A., Mikhaylov E.V. THE EFFECT OF ENROFLOXAVETFERON AND GENTABIFERON-B ON BLOOD PARAMETERS OF COWS IN THE TREATMENT OF ENDOMETRITIS. International Journal of Veterinary Medicine. 2024;(4):152-160. (In Russ.) https://doi.org/10.52419/issn2072-2419.2024.4.152
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