Pathogenetic substantiation of pharmacotherapy of ulcerative gastroduodenitis in animals and application prospects narrow-leaved sucker in pathology (review)

The leading place among diseases of non -infectious etiology in productive animals is occupied by diseases of the digestive tract. The article discusses the pathogenetic mechanisms of ulcerative gastroduodenitis development, modern approaches to pharmacotherapy of the disease and prospects for the use of herbal remedies based on oleaster. An analysis of publications by keywords, "oleaster", "pharmacological effects", "herbal remedy", "gastritis", "peptic ulcer disease", "medicinal plants", posted in bibliographic databases and scientific electronic libraries of search engines. The existing pharmacotherapeutic approaches to the treatment of ulcerative gastroduodenitis, including herbal preparations, were studied, and data on biologically active substances contained in narrow-leaved oleaster were searched and analyzed, with an emphasis on their potential therapeutic effect in ulcerative gastroduodenitis. The main pathogenetic factor of peptic ulcer disease is damage to the mucous membrane of the stomach and duodenum under the influence of excessive production of hydrochloric acid and pepsin with the subsequent development of oxidative stress and disruption of its barrier function. Frequent use of non-steroidal antiinflammatory drugs (NSAIDs) for therapeutic purposes in animals contributes to the development of NSAID-induced gastropathy. Modern therapy of ulcerative gastroduodenitis in unproductive animals is based on the use of synthetic drugs - blockers of H+ and H2 - histamine receptors, antacids and sorbents. A promising direction in the therapy of ulcerative gastroduodenitis is the use of herbal preparations with proven gastroprotective activity, such as powder of rhizomes and roots of elecampane, flax seeds, plantain and preparations based on calendula officinalis. As a source of biologically active substances for the production of herbal preparations / feed additives with a gastroprotective effect, it is possible to use raw materials of oleaster - a plant containing a significant number of tannins, flavonoids, carotenoids and alkaloids, aqueous extracts from the fruits of which have wound-healing, antiinflammatory, antimutagenic, antimicrobial properties.

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