Study of acute toxicity of a complex antimycotic drug

Abstract

Conducting preclinical studies is an important stage for the introduction of new pharmacological drugs into clinical practice. A prerequisite for this is to conduct toxicological studies. The article presents the results of studying the parameters of acute toxicity of the new antimycotic drug "Fungicor". The experiments were conducted on laboratory nonlinear white rats and mice. The acute toxicity of the drug was studied with intragastric, subcutaneous and subcutaneous administration. It was found that the dose range of the drug from 4000 to 10000 mg / kg body weight for mice and from 4000 to 12000 mg / kg body weight for rats with intragastric administration did not lead to the death of laboratory animals. The vital signs were within the physiological norm and did not differ from the values of the control animals. The maximum tolerated dose (MTD) of "Fungicor" for mice and rats was 10,000 mg/kg and 12,000 mg/kg body weight, respectively. Subcutaneous administration in doses from 4000 to 8000 mg / kg body weight for mice and from 4000 to 10000 mg / kg body weight for rats also did not reveal a negative effect of the drug on the general condition of experimental animals. The maximum tolerated dose was 8000 mg/ kg and 10000 mg/kg, respectively. When studying the cutaneous toxicity of the drug in doses from 1500 to 15000 mg / kg of body weight, the death of experimental mice and rats was not noted. In connection with the above, it can be concluded that the drug "Fungicor" according to GOST 12.1.007-76 belongs to hazard class IV (low-risk substances).