The metabolic role of the organo-mineral supplement klim in experimental liver replication in rats

The use of feed additives in veterinary medicine has recently become increasingly important due to the need to reduce the impact of negative environmental factors or factors arising from improper animal husbandry practices. They contribute to the improvement of the overall health of animals, and their use also reduces treatment costs and increases farm profitability. The aim of this study was to investigate the effect of the feed additive Klim on key biochemical parameters of rat liver blood during a model of acute toxic hepatitis with the toxic substance carbon tetrachloride (CCl4). The discovery and development of new hepatoprotectors is one of the most important tasks in the field of pharmacology. The pathogenesis of liver damage includes oxidative stress, inflammatory processes, apoptosis or necrosis, mitochondrial dysfunction, cholestasis, activation of hepatic stellate cells, and fibrosis. This provides ample scope for the development of hepatoprotectors targeting specific molecular pathways (antioxidants, anti-inflammatory agents, antifibrotics, metabolic modifiers, etc.). The need to search for and develop new hepatoprotectors for animals is justified by the high prevalence of liver problems in various species, significant economic losses in livestock farming, risks to food security, the limitations of existing, often poorly proven, treatments, species-specific metabolism and drug response, and the importance of improving animal welfare. The development of safe, effective, and tailored hepatoprotectors will strengthen veterinary practice, reduce costs, and improve the quality of animal products. The study demonstrated that the use of the dietary supplement Klim in acute toxic poisoning contributes to improvements in key blood biochemical parameters in a model of acute toxic hepatitis in rats.

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