Study of the embryotoxic and teratogenic effects of the feed additive «Complisorbin»

The feed additive «Complisorbin» based on shungite, zeolite, lignin and glucan is intended for use in animal feed. It is known that such sorbents are used to detoxify mycotoxins and improve reproductive health, therefore, the study of their embryotoxic and teratogenic effects is an important step in preclinical evaluation. For this purpose, three groups of nonlinear white rats were formed, with 20 animals each. Animals of the first and second groups were given a suspension of the feed additive «Complisorbin» in distilled water daily from 1st to 19th day of pregnancy, at the rate of 250 and 500 mg/ kg body weight. The dosage of the feed additive was calculated individually for each animal. The third group served as biological control and received distilled water. According to the results, fetal mortality was reduced to 3,91±0,24 % (500 mg/kg) versus (6,98±0,34 %) in the control. In addition, the weight gain rates of females (103,5—105,4 g), the weight of baby rats (62,75—69,56 g by day 28) and the timing of reflexes (ear detachment 3,75—3,88 days) did not differ from the norm. Thus, the results of the study indicate the absence of embryotoxic and teratogenic effects of the feed additive «Complisorbin» in these doses in both the antenatal and postnatal periods of development of baby rats.

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