Treatment of experimental wounds in cattle using rv-1 and rv-2 immunomodulators and hydrogen peroxide

According to literature data, it is shown that one of the promising directions in in creasing the effectiveness in the treatment of wounds of various genesis and the prevention of postoperative complications is a comprehensive treatment based on targeted and combined immunocorrection using drugs with different mechanisms of action and attachment points. It is noted that in most cases immunomodulators are used as injections but at the same time local correction of wound defects is of interest. Experiments were carried out on 20 heads of young cattle of nine months age distributed into four groups - a control group and three experimental ones (n = 5 in each). All animals undergone a cutaneous muscle wound modeling. The heifers of the control group were not treated (the model of the untreated wound), in the experimental groups 72 hours after wounding they were locally treated daily for 5 days: the first group - with hydrogen peroxide, the second one - with the immunomodulator RV-1 from the group of natural compounds on an alcoholic basis, representing a complex balanced composition of biologically active substances and the third group - with immunomodulator RV-2 from the group of synthetic dipeptides. It is shown that the effect of drugs with a local application was of a varied nature. In the first 3 days in the control, 1st and 3rd experimental groups the wound defect was increased by 9.4; 7.5 and 11.8%, respectively, but with a reduction in wound area in the second group of experimental animals where the immunomodulator RV-1 was applied. Further, the most pronounced wound healing effect (reduction in area and increase in wound healing speed) in comparison with the control group the was manifested by immunomodulator of natural origin - RV-1 ,to a lesser extent - by hydrogen peroxide and a preparation from the group of synthetic dipeptides. This was reflected in the timing of wound healing - 15.6 ± 1.2 days compared to 18.2 ± 1.46; 17.2 ± 1.32 and 17.8 ± 1.53, respectively. Summarizing the problem of large-scale use of immunomodulators in the practice of veterinary surgery, it should be noted that it is in most cases empirical and is still far from being resolved.

иммуномодуляторы, локальная иммунокоррекция, инфицированная кожно-мышечная рана, телки, перекись водорода, площадь раны, скорость заживления, продолжительность болезни, immunomodulators, local immunocorrection, infected skin and muscular wound, heifers, hydrogen peroxide, area of a wound, healing speed, disease duration

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