Complex algorithm for correction of redox-homeostasis and functional disorders of the hepatorenal system in cats with chronic kidney disease (CKD) third stage (moderate renal azotemia) according to IRIS

Abstract

Correction of chronic kidney disease (CKD) of the third stage (moderate renal azotemia) according to IRIS in cats should be carried out in a complex manner, taking into account the nature of the correlative relationships of redox homeostasis and functional disorders of the hepatorenal system. The additional antioxidant support of the organism as part of a complex scheme for the correction of chronic kidney disease (CKD) of the third stage (moderate renal azotemia) according to IRIS in cats contributed to the optimization of redox homeostasis (MDA– 18.45±1.38 µmol/ml and 24.96±1.07 µmol/ml DK - 0.43±0.03 uA/ml and 0.76±0.05 uA/ml CT - 0.56±0.02 Bach units and 0.41±0.02 Bach units ), normalization of indicators of functional activity of the components of the hepatorenal system (SDMA - 16.09±3.45 ug/dL and 21.32±3.05 ug/dL; UREA - 22.58±3.30 μmol/l and 28.73± 2.94 µmol/l, CREA - 252.91±9.35 µmol/l and 299.24±8.03 µmol/l, ALT - 56.89±5.10 U/l and 73.06±3.45 U /l, AST - 23.40±2.91 U/l and 26.71±2.17 U/l, ALP - 24.08±1.39 U/l and 28.93±1.60 U/l ), which in turn contributed to the correction of the level of metabolic processes of the body (T-Pro - 66.81±1.32 g/l and 72.86±2.60 g/l; GLB - 34.61±2.06 g/ l and 40.88±1.90 g/l, A/G - 0.93±0.02 and 0.78±0.03, P - 2.25±0.14 mmol/l and 2.70± 0.12 mmol/l Ca - 2.09±0.04 mmol/l and 1.89±0.10 mmol /l).