Study of the therapeutic efficacy of okvet
https://doi.org/10.52419/issn2072-2419.2023.1.64
Abstract
Due to the ability of ixodid ticks to transmit pathogens transovarially and transphasically, natural foci of dangerous diseases are formed, which is important for preventive measures. Of particular danger are foci of diseases that have formed on the territory of settlements. The aim of our study was to determine the therapeutic efficacy of the insectoacaricidal drug for veterinary use "OKVET Tabs Express for dogs". In the period from June 24 to August 27, 2022, the study drug was tested on 28 dogs of both sexes with a confirmed diagnosis of ixodidosis aged from 10 months to 10 years in the farms of the Meghri district of the Syunik region of the Republic of Armenia. The species affiliation of ticks found in the studied dogs was determined jointly with the specialists of the Laboratory of Molecular Parasitology of the Scientific Center of Zoology and Hydroecology of the National Academy of Sciences of the Republic of Armenia using determinants. According to the results of the experiment, it was found that 40% of all ixodid ticks found on dogs were R. turanicus Pomerantsev 1936, and ticks R. sanguineus Latreille, 1806 and H. scupense Schulze, 1919 were found in 30% of cases. After a single oral administration of the drug, we did not observe the presence of ticks in animals during daily examination for 65 days. In animals during the entire experiment, no deviations from physiological norms and anxiety were found, signs of allergic and other visible side effects were not detected
About the Authors
R. V. Slobodyanik
Federal State Budgetary Educational Institution of Higher Education "St. Petersburg State University of Veterinary Medicine"
Russian Federation
Russian Federation
PhD in Veterinary sciences, Competitor of the Department of Pharmacology and Toxicology
S. S. Zykova
Federal State Budgetary Educational Institution of Higher Education «Perm State Pharmaceutical Academy of the Ministry of Health of Russian Federation»
Russian Federation
Russian Federation
Grand PhD in Biological sciences, Associate Professor, Head of the Department of Pharmacology
A. M. Lunegov
Federal State Budgetary Educational Institution of Higher Education «Perm State Pharmaceutical Academy of the Ministry of Health of Russian Federation»
Russian Federation
Russian Federation
PhD in Veterinary sciences, Associate Professor, Head of the Department of Pharmacology and Toxicology
O. V. Shcherbakov
3Scientific Center of Zoology and Hydroecology, National Academy of Sciences of the Republic of Armenia
Armenia
Armenia
Senior Researcher at the Laboratory of Molecular Parasitology, PhD in biology
E. S. Engasheva
Federal State Budgetary Scientific Institution All-Russian Research Institute for Veterinary Sanitation, Hygiene and Ecology
Russian Federation
Russian Federation
Senior Researcher, Laboratory of Pharmacology and Toxicology, Grand PhD in Biological sciences
References
1. Balashov, Yu. S. Ixodid ticks - parasites and vectors of infections. - St. Petersburg: Nauka, 1998. - 287 p. (in Russian)
2. Balashov, Yu. S. Parasitism of ticks and insects on terrestrial vertebrates / Yu. S. Balashov // Russian acad. Sciences, Zoological Institute. - St. Petersburg: Nauka, 2009. - ISBN 978-5-02-026336- 9. (in Russian)
3. Belova, L. M. Arachnoentomoses of productive and small domestic animals / L. M. Belova, N. A. Gavrilova, Yu. E. Kuznetsov [and others]. - St. Petersburg: Limited Liability Company "Prospect Nauki", 2022. – 187 p. (in Russian)
4. Ivaylovskaya, Yu. I. Results of epidemiological monitoring of natural focal infections in the Irkutsk region in 2017-2021 / Yu. I. Ivaylovskaya, M. I. Khakimova, O. L. Bogomazova // Sanitary and epidemiological well-being of the population and protection of rights consumers: regional aspects: materials of the All-Russian scientific and practical conference dedicated to the 100th anniversary of the formation of the State Sanitary and Epidemiological Service of Russia, Irkutsk, September 23, 2022. - Irkutsk: IRKUT Printing House LLC, 2022. - P. 240-243. (in Russian)
5. Belimenko, V. V. Features of the formation of biotopes of ixodid ticks on the territory of Moscow / V. V. Belimenko, P. I. Khristianovsky, E. V. Novosad, A. M. Gulyukin // Modern problems of general and particular parasitology: Materials III International Parasitological Symposium, St. Petersburg, December 18–20, 2019. - St. Petersburg: St. Petersburg State Academy of Veterinary Medicine, 2019. - P. 53-56. (in Russian)
6. Malkova, M. G., Yakimenko V. V., Tantsev A. K. Changes in the range boundaries of Ixodes pasture ticks of the genus Ixodes Latr., 1795 (Parasitiformes, Ixodidae) in Western Siberia // Parasitology . - 2012. - T. 46. - No. 5. - S. 369-383. (in Russian)
7. Vdovina, E. D., Shchetnikova E. A., Noskov M. A. The role of Dermacenter reticulatus ticks (Parasitiformes, Ixodidae) in the spread of piroplasmosis in dogs of the Kemerovo region // Status and prospects for the development of the agroindustrial complex : anniversary collection of scientific papers of the XIII International Scientific and Practical Conference dedicated to the 90th anniversary of the Don State Technical University (Rostov-on-Don Institute of Agricultural Engineering), within the framework of the XXIII Agro- Industrial Forum of the South of Russia and the Interagromash exhibition. In 2 volumes, Rostov-on -Don, February 26–28, 2020. Volume 1. - Rostovon- Don: Limited Liability Company "DSTUPRINT", 2020. - P. 433-435. – DOI 10.23947/ interagro.2020.1.433-435. (in Russian)
8. Nyshanov, N. S. Epidemiological surveillance of the incidence of CCHF in the Turkestan region of the Turkestan region of the Republic of Kazakhstan in 2006-2018 / N. S. Nyshanov, A. R. Kuzmina, A. O. Orynkozha // National priorities of Russia. - 2021. - No. 3(42). - S. 225-228. (in Russian)
9. Engashev, S. V. Seasonal dynamics of the activity of horseflies, blood-sucking, licking zoophilous flies and the effectiveness of synthetic pyrethroids in the form of a solution and ear insect-acaricidal tags / S. V. Engashev, M. D. Novak, M. A. Aliev [ etc.] // Issues of legal regulation in veterinary medicine. - 2019. - No. 2. - P. 49-54. (in Russian)
10. Khristianovsky, P. I. Phenology of ixodid ticks in the Southern Urals / P. I. Khristianovsky, V. V. Belimenko, I. V. Bystrov, E. V. Novosad // Russian Journal of Parasitology. - 2016. - No. 2. - P. 141-147. (in Russian)
11. Osmolovsky, A. A. Ixodid ticks as carriers of pathogens of infectious diseases and their distribution in the Vitebsk region / A. A. Osmolovsky // Actual problems of infectious pathology of animals and ways to solve them: materials of the International scientific and practical conference dedicated to the Day of Belarusian Science and the 95th anniversary of the Department of Epizootology and Infectious Diseases, Vitebsk, December 15–16, 2022. - Vitebsk: Educational Institution "Vitebsk Order "Badge of Honor" State Academy of Veterinary Medicine", 2023. - P. 220-223. (in Russian)
12. Engashev, S. V. Efficiency of insectoacaricidal collars Bars against fleas, ixodid ticks in dogs and cats / S. V. Engashev, E. S. Engasheva, M. D. Novak, A. M. Reason // International Bulletin of Veterinary Medicine . 2013. - No. 3. - From 6-9. (in Russian)
13. Bondarenko, V. O. New insectoacaricidal preparations: pharmaco-toxicological properties, standardization and disposal methods: specialty 16.00.04: dissertation for the degree of Doctor of Biological Sciences / Bondarenko Vladimir Olegovich. - Moscow, 2005. - 326 p. (in Russian)
14. Udavliev, D. I. Insectoacaricidal agents based on pyrethroids and cyodrin in the form of polymer products, aerosols, emulsions and foams: specialty 06.02.05 "Veterinary sanitation, ecology, zoohygiene and veterinary and sanitary examination", 06.02.03 "Veterinary pharmacology with toxicology": abstract of the dissertation for the degree of Doctor of Biological Sciences / Udavliev Damir Ismailovich. - Moscow, 2011. - 46 p. (in Russian)
15. A. Estrada-Peña, A. Bouattour, J.-L. Camicas, A.R. Walker Ticks of Domestic Animals in the Mediterranean Region. A Guide to Identification of Species. University of Zaragoza, 2004.
Review
For citations:
Slobodyanik R.V., Zykova S.S., Lunegov A.M., Shcherbakov O.V., Engasheva E.S. Study of the therapeutic efficacy of okvet. International Journal of Veterinary Medicine. 2023;(1):64-70. (In Russ.) https://doi.org/10.52419/issn2072-2419.2023.1.64
Views:
502
Email this article 