Evaluation of the possibility of using indicators of the blood coagulation system of cows to predict late toxicosis of pregnant women

Abstract

Indicators of  the blood  coagulation  system (thrombin time, prothrombin time, activated  partial  thromboplastin  time -  aPTT) were studied on 42 pregnant cows at 60-75, 135-150  and  210-230  days  of  pregnancy, divided  according  to  the  principle  of  analogues  into  three  groups:  physiological course,  fetal  growth  restriction  syndrome without  late  toxicosis  of  pregnancy,  fetal growth restriction syndrome complicated by gestosis.  Pregnancy  was  diagnosed  using transrectal  and  ultrasound  examinations. Fetal growth restriction syndrome was diagnosed at 60-75 days of pregnancy using an ultrasound scanner with a linear sensor with a  frequency  of  7.5  MHz.  Late  toxicosis  of pregnant animals was diagnosed at 210-230 days of pregnancy by the presence of hypertension, proteinuria and edema. Blood samples were taken from the animals included in the experiment to determine the platelet content,  thrombin  and  prothrombin  time  and aPTT.  It  has  been  established  that  platelet content is an informative indicator for predicting  gestosis  in  the  first  five  months  of pregnancy  with  a  sensitivity  of  80.0%  and specificity  of  87.5%.  The  sensitivity  of thrombin time at 60-150 days of pregnancy is  77.8%,  specificity -  90.0%,  prothrombin time  -  70.0  and  88.9%,  aPTT  at  135-150 days of pregnancy - 77.8 and 85.7%, respectively. Prognostic markers for early diagnosis of late toxicosis in pregnant animals, determined  at  2  months  of  pregnancy  are: platelet  level -  451.2  x  10⁹/L  and  higher; thrombin  time –  87.3 seconds  and  below; prothrombin time – 35.1 seconds and below. Indicators  for  early  diagnosis  of  gestosis, determined  at  5  months  of  pregnancy,  are: platelet  level -  437.5  x  10⁹/L  and  higher; thrombin  time –  78.6 seconds  and  below; prothrombin time – 30.3 seconds and below; aPTT – 41.8 sec and below.