Application of antioxidant anti - inflammatory drug in complex schemes of endometritis therapy in cows

This work presents the results of a study of the effectiveness of using a new antioxidant anti-inflammatory drug for animals developed in the Stavropol State Agrarian University as part of a comprehensive treatment regimen for purulent-catarrhal endometritis in cows. The studies were conducted using 30 cows of the 4-7 years old with purulent-catarrhal endometritis. Animals were divided into three equal groups according to the principle of analogues. In all groups, a standard therapy regimen was used, including the administration of antibiotics, immunostimu-lants, hormonal and vitamin agents. Additionally, in the second group, the Flunex drug was administered intramuscularly at therapeutic doses in the first three days of treatment, and in the third group, the tested antioxidant anti-inflammatory drug was similarly. It was established that against the background of purulent-catarrhal endometritis, intensification of lipid peroxidation is observed, manifested by an increase in its products in the blood. Addition of an antiinflammatory treatment regimen contributed to a decrease in the erythrocyte sedimentation rate and the number of leukocytes in the blood of experimental animals. The use of an antioxidant anti-inflammatory drug significantly led to an increase in the level of activity of glutathione peroxidase, superoxide dismutase and glutathione, and normalization of the concentration of diene conjugates and malondialdehyde in the blood of cows. The use of “Flunex” and “Antioxidant antiinflammatory drug for animals” preparations contributed to a decrease in the duration of manifestation of the main clinical signs of endometritis and a decrease in the duration of uterine involution after the disease. Their positive effect on the reproductive ability of cows was noted, which consisted in a reduction in the frequency of insemination and a decrease in the duration of the service period.

коровы, эндометрит, воспаление, антиоксиданты, воспроизводство, перекисное окисление липидов, cows, endometritis, inflammation, antioxidants, reproduction, lipid peroxidation

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