The relationship between the occurrence of anterior synechiae and localization of a burn wound of the cornea

Abstract

The objective of this study was to determine the relationship between the occurrence of anterior synechiae and the localization of a burn wound of the cornea. For this purpose, 10 male Wistar rats were selected, one year old, with an average weight of 200 grams (two experimental groups of 5 rats each). Wounds were inflicted on animals injected into sevoflurane anesthesia by touching the cornea with the tip of a copper rod having 1.0 mm in diameter and heated to t – 480-500 °C. The required degree of burn was achieved by the time of contact of the thermal source with the cornea and was monitored visually with an increase of 4-6 times. A 10% lidocaine solution was used for local anesthesia. 1.0% atropine solution was used to remove the iris from the zone of phlogogen exposure. Corneal wounds were inflicted on rats in the first experimental group in the central region, and on rats in the second experimental group in the projection area of the iris.
The observation was carried out for three weeks with constant monitoring and photodocumentation of the wound condition using a microscope "jingleszcn 315W" at magnification x 6.0. The study was carried out before instillation of atropine and 10.0 minutes after.
The experiment showed that significant differences in the course of the wound process were observed by day 15, there were no anterior synechiae in the experimental group 1, while in animals in the experimental group 2, the reaction of the iris to atropine shows the inability to open the pupil evenly around the circumference, which indicates the presence of a adhesion process.
Thus, the results of the conducted studies have shown that the probability of the development of iridocorneal synechiae depends on the location of the inflammatory process on the cornea.