Immunometabolic risks in calves during the period of changing the type of feeding and the possibility of their pharmacological adjustment
https://doi.org/10.52419/ISSN2072-2419.2024.2.141
Abstract
Most diseases of young animals are initiated by pathologies of non-contagious etiology, such as disorders of degenerative processes, the imbalance of metabolism in the occurrence of which the leading role belongs to negative environmental factors. The purpose of our work was to study the state of the immune system and metabolism in calves during the period of changes in the type of feeding and the possibility of pharmacological correction of their disorders. An experiment was conducted on a dairy farm located in the Pscov’s region, the object of which was clinically healthy heifers. To conduct the experiment, using the method of selecting analogues, two groups of clinically healthy calves were formed at the age of 52 days: № 1 (control, n = 60) animals received feed in accordance with the technology, № 2 (n = 62) - in addition to basic diets, calves received three courses of 7 days with an interval of 5 days of sorption-metabolic premix at a dose of 0.20 g/kg per day. This feed additive has the properties of an enterosorbent, hepatoprotective and ruminoprotective agent, and its constituent flavonoids and humic acid affect the immune system. During the period of the experiment, i.e., from 53 to 86 days of life, calves undergo metabolic restructuring, which puts a functional load on all body systems with a corresponding risk of disruption of their functions. In particular, there is a risk of biochemical deficiency syndrome in the rumen, toxic liver dystrophy and anemia, the initiating factor of which, as our research has shown, is endogenous toxins, including proinflammatory interleukins. The administration of the phytopos-rum premix eliminated the accumulation of endotoxins and has a hepatoprotective effect, which reduces the risks of metabolic disorders, liver and bone marrow functions and digestive processes in the rumen, and increases the metabolic and immunological uniformity of the livestock.
About the Authors
O. S. Popova
FSBEI HE St. Petersburg GUVM
Russian Federation
Russian Federation
Ph.D. of Veterinary Science, Associate Professor Pharmacology and Toxicology
P. A. Parshin
All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy
Russian Federation
Russian Federation
doctor of veterinary sciences, professor, director
Y. N. Alеkhin
All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy
Russian Federation
Russian Federation
doctor of veterinary sciences, chief researcher of the experimental therapy department
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Review
For citations:
Popova O.S., Parshin P.A., Alеkhin Y.N. Immunometabolic risks in calves during the period of changing the type of feeding and the possibility of their pharmacological adjustment. International Journal of Veterinary Medicine. 2024;(2):141-150. (In Russ.) https://doi.org/10.52419/ISSN2072-2419.2024.2.141
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