Evaluation of the efficacy of microbial strains in vaccines for the prevention of salmonellosis in animals
https://doi.org/10.52419/issn2072-2419.2024.3.58
Abstract
Animal salmonellosis is an infectious disease affecting a wide range of productive animals. Vaccination of animals is one of the effective ways to combat salmonellosis and remains in demand in veterinary practice. On the territory of the Russian Federation more than 30 vaccines against salmonellosis in animals are used. Conventionally, means of specific immunoprophylaxis against salmonellosis can be divided into two groups: vaccines against avian salmonellosis and vaccines against salmonellosis of other animal species. Production strains are usually derived from isolates isolated from animals in salmonellosis epizootics in the vaccineproducing countries. Inactivated vaccines against avian salmonellosis, represented by preparations, mainly, of foreign manufacturers are made on the basis of cultures obtained from strains of S. Enteritidis, S.Typhimurium and S.Infantis, which corresponds to the etiological structure of animal and human salmonellosis morbidity. Among the means of immunoprophylaxis of salmonellosis in cattle and pigs, used in the territory of the Russian Federation, there are no preparations of foreign manufacturers, and the etiological structure of the disease in these species of animals for many years remains unchanged. Domestic vaccines are developed on the basis of production strains, reference samples of which are deposited in the relevant state collections, the updated list of which is approved by the Order of the Government of the Russian Federation from 06.09.2021 № 2460-r. The majority of vaccines against salmonellosis in animals, excluding birds, used in the territory of the Russian Federation are made on the basis of S. choleraesuis strains. Choleraesuis 370, S. Typhimurium 371 and S. Dublin 373, selected in FGBU "VGNKI", which indicates their sufficient efficiency and epizootic significance at present.
Supporting agencies: the work was supported by the Federal Service for Veterinary and Phytosanitary Surveillance within the framework of the research project: "Diagnosis of the state of normal microbiota of the gastrointestinal tract of poultry under the influence of antimicrobial and probiotic preparations for the development and implementation of measures to preserve or restore it" from 25.12.2023 № 081-00008-24-00.
About the Authors
O. V. Prasolova
The Russian State Center for Animal Feed and Drug Standardization and Quality
Russian Federation
Russian Federation
Prasolova O.V. - Candidate of Sciences (Veterinary medicine), Leading researcher of the Molecular Biology Department
S. V. Lenev
The Russian State Center for Animal Feed and Drug Standardization and Quality
Russian Federation
Russian Federation
Lenev S.V. - Candidate of Sciences (Biology), Leading researcher of the science and technology laboratory
References
1. Jajere SM. A review of Salmonella enterica with particular focus on the pathogenicity and virulence factors, host specificity and antimicrobial resistance including multidrug resistance. Vet World. 2019;12(4):504-521. doi: 10.14202/vetworld.2019.504-521. Epub 2019 Apr 6. PMID: 31190705; PMCID:PMC6515828.
2. Sears K. T., Galen J. E., Tennant S. M. Advances in the development of Salmonella‐ based vaccine strategies for protection against Salmonellosis in humans //Journal of Applied Microbiology. – 2021. – Т. 131. – №. 6. – С. 2640-2658. https://doi.org/10.1111/jam.15055
3. Weerakhun S., Kongsanan P., Kongkham W. Distribution of Salmonella spp. and serovars isolated from captive reptiles in four zoos of the Zoological Park Organization, Thailand, between 2017 and 2018 //The Thai Journal of Veterinary Medicine. – 2022. – Т. 52. – №. 2. – С. 349-358. https://doi.org/10.56808/2985-1130.3224
4. Ленев, С.В., Совершенствование методов выделения и идентификации бактерий рода Salmonella подвида Arizonae. / С.В. Ленев, А.И. Лаишевцев, Н.В. Пименов // Russian Journal of Agricultural and Socio-Economic Sciences. – 2018. - №2 (50). – P. 14-23
5. Information Bulletin of the Reference Centre for Salmonellosis Monitoring, No. 35, Moscow, 2023.
6. Lamichhane B, Mawad AMM, Saleh M, Kelley WG, Harrington PJ 2nd, Lovestad CW, Amezcua J, Sarhan MM, El Zowalaty ME, Ramadan H, Morgan M, Helmy YA. Salmonellosis: An Overview of Epidemiology, Pathogenesis, and Innovative Approaches to Mitigate the Antimicrobial Resistant Infections. Antibiotics (Basel). 2024 Jan 13;13(1):76. doi: 10.3390/antibiotics13010076. PMID: 38247636; PMCID: PMC10812683.
7. Prasolova, O. V. Analysis of research and development of vaccines in the world / O. V. Prasolova, D. G. Isakova, G. Y. Kosovsky // Veterinary Medicine. - 2024. - № 4. - P. 35-38. DOI 10.30896/0042-4846.2024.27.4.35-38.
8. Lenev, S. V., Biological Properties and Genetic Characteristics of Collection and Epizootic Strains of Salmonella / S. V. Lenev, E. V. Krylova, V. D. Gordeeva [et al.] // International Transaction Journal of Engineering, Management and Applied Sciences and Technologies. – 2022. – Vol. 13, No. 12. – P. 1312. – DOI 10.14456/ITJEMAST.2022.243.
9. Identification of resistance genes in the framework of veterinary monitoring / Prasolova O.V., Krylova E.V., Soltynskaya I.V., Putintseva A. V.,Timofeev I.А., Kirsanova N.A., Osipova Yu. A., Ivanova O.E., Kish L.K. // International bulletin of Veterinary Medicine. – 2023. – № 2. – P. 77-85. – DOI 10.52419/issn2072-2419.2023.2.77.
10. Application of full-genome sequencing methods in the structure of epizootological monitoring of multidrug-resistant pathogens / O. V. Prasolova, N. A. Kirsanova, G. V. Konovalova [et al] // Knowledge of the young for the development of veterinary medicine and agro-industrial complex of the country : Proceedings of the X anniversary international scientific conference of students, postgraduates and young scientists, dedicated to the year of science and technology, St. Petersburg, 23-24 November 2021. - St. Petersburg: St. Petersburg State University of Veterinary Medicine, 2021. - P. 294-295.
11. Study of biological properties of strains of pathogens of infectious diseases of animals isolated in the Russian Federation and their comparison with pathogens in collections, including those common to humans and animals, in order to assess the variability of their cultural and morphological properties, pathogenicity, as well as to study their resistance to environmental factors and disinfectants. Research of new effective means and methods of disinfection: methodical recommendations / E. D. Javadov, A. A. Sukhinin, S. A. Makavchik [et al.]. - St. Petersburg: St. Petersburg State University of Veterinary Medicine, 2021. – 35.
12. Methods of diagnostics of diseases of farm animals: textbook for universities / A. P. Kurdeko, S. P. Kovalev, V. N. Aleshkevich [et al.]. - 3rd edition, stereotype. - Saint-Petersburg: Publishers "Lan", 2021. - 208 с. - (Textbooks for universities. Special literature). - ISBN 978-5-8114-8317-4.
13. Molecular biology / L. Yu. Karpenko, A. A. Bakhta, A. I. Kozitsyna [et al.]; Karpenko L. Yu. - Saint-Petersburg: Saint-Petersburg State University of Veterinary Medicine, 2020. - 240 с.
Review
For citations:
Prasolova O.V., Lenev S.V. Evaluation of the efficacy of microbial strains in vaccines for the prevention of salmonellosis in animals. International Journal of Veterinary Medicine. 2024;(3):58-66. (In Russ.) https://doi.org/10.52419/issn2072-2419.2024.3.58
Views:
88
Email this article 