Evaluation of the embryotoxic and teratogenic effects of a new complex antimycotic drug

Abstract

Fungal pathogens – dermatophytes are often the main cause of skin diseases in agricultural and domestic animals. These pathogens can cause superficial fungal infections – dermatophytosis. The market of veterinary drugs for the treatment of animals with dermatophytosis is represented by a wide range of antimycotic agents, however, treatment regimens using available drugs often become insufficiently effective, since dermatophytes infecting the skin become resistant to them. At the same time, certain pharmacological preparations, when ingested with food or as a result of external treatments, can negatively affect the physiological state of animals, in particular their reproductive function. The paper presents an assessment of the embryotoxic and teratogenic effects recorded in the antenatal and postnatal periods of development of the offspring of white rats with the external use of a new complex antimycotic agent against dermatophytosis of animals "Fungicor". It was found that the drug in the minimum (1500 mg / kg body weight) and maximum (15,000 mg / kg body weight) doses when applied to female white rats from the 1st to the 19th day of pregnancy did not have an adverse effect on the development of embryos and fetuses. There were no significant changes in the parameters of postnatal development of the offspring of the experimental groups in comparison with the control. Thus, the drug "Fungicor" does not have an embryotoxic and teratogenic effect.