PHAGOCYTIC INDICES OF BLOOD PSEUDOEOSINOPHILS WITH THE USE OF CIPROFLOXACIN AND ENROFLOXACIN

Abstract

The effect of drinking ciprofloxacin and enrofloxacin at a dose of 200 mg/l on phagocytosis of pseudoeosinophils in the blood of chickens was studied. Ciprofloxacin and enrofloxacin are antibacterial drugs of the fluoroquinolone group used in veterinary medicine. The most common use of these drugs in poultry farming is due to their excellent pharmacodynamic and antimicrobial properties. The aim of the work is to study the effect of fluoroquinolones on the phagocytosis of pseudoeosinophils. The study involved three groups consisting of day-old chickens of the Haysex Braun cross. Chickens of group I (control) received clean water, while in groups II and III ciprofloxacin and enrofloxacin were soldered for 10 days with water at a dose of 200 mg/l. Blood sampling was performed on the 1, 3, 5, 7 and 9 days after drug withdrawal. The phagocytic activity, phagocytic number, phagocytic index and phagocytic capacity of pseudoeosinophils were studied after co-incubation for 30 and 120 minutes with a culture of Staphylococcus aureus. As a result of the conducted studies of the effect of fluoroquinolones on the phagocytic reaction, no significant negative effects of the drugs were revealed. The main changes during incubation of pseudoeosinophils together with St. aureus were registered on the third and fifth days. Enrofloxacin caused shifts after 30-minute incubation with St. aureus, which manifested itself in a significant but not prolonged decrease in phagocytic activity, as well as an ambiguous short-term decrease followed by an increase in the phagocytic index and phagocytic number. All registered changes were short-lived.