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SENSITIVITY OF BACTERIA TO ANTIBIOTICS MASTI BLOCK® DC 49, MASTIC-P, MASTERCARD WITH MASTITIS OF DRY COWS

https://doi.org/10.52419/issn2072-2419.2024.4.161

Abstract

In the etiology of mastitis, pathogenic bacteria Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysgalactiae, Corynebacterium bovis and a number of others are of paramount importance. Frequent unjustified use of antibacterial drugs without prior determination of effectiveness against microorganisms in a particular farm led to the formation of resistant isolates. The aim of the research was to study the sensitivity of bacterial strains isolated from cows with mastitis to the antibacterial drugs MASTIBLOCK® DC 49, MASTICAN-P and MASTIGARD. The research was carried out in a large dairy complex in the Central district of the Russian Federation. The experimental groups included cows with clinical signs (No. 1) and subclinical form (No. 2) of mastitis with positive results of studies using the KENOTEST reagent. Antibiotic sensitivity of bacterial isolates isolated from milk was determined by the cylinder method. In cows with a subclinical and clinically pronounced form of mastitis, Staphylococcus aureus, Corynebacterium spp., Streptococcus agalactiae, Bacillus spp. (β-hemolytic isolates) were isolated during bacteriological examination. The maximum effectiveness of MASTIBLOCK® DC 49 has been established in the subclinical serous-catarrhal form of mastitis, mainly against Grampositive bacteria. MASTIGARD has a wider range of antimicrobial effects, including on strains producing β-lactamase and inhibiting the action of penicillin antibiotics. The results obtained allow us to recommend the use of the complex antibiotic MASTIBLOCK® DC 49 not only during the dry season, but also during lactation to stop bacterial infection of the breast in cows, while observing the appropriate technology of milking and milk processing.

About the Authors

S. V. Engashev
Moscow State Academy of Veterinary Medicine and Biotechnology – MBA named after K.I. Scriabin
Russian Federation

Engashev S.V. – Professor, Doctor of Veterinary Sciences, Academician of the Russian Academy of Sciences, Professor of the Department of Parasitology and Veterinary and Sanitary Expertise



M. D. Novak
Ryazan State Medical University named after Academician I.P. Pavlov
Russian Federation

Novak M.D. – Professor, Doctor of Biology, Professor of the Department of Epidemiology



A. I. Novak
Ryazan State Medical University named after Academician I.P. Pavlov
Russian Federation

Novak A.I. – Associate Professor, Doctor of Biology, Professor of the Department of Microbiology



O. V. Evdokimova
Ryazan State Medical University named after Academician I.P. Pavlov
Russian Federation

Evdokimova O.V. – Associate Professor, Candidate of Medical Sciences, Head of the Department of Microbiology



E. S. Engasheva
Federal Scientific Center – All-Russian Scientific Research Institute of Experimental Veterinary named after K.I. Scriabin and Ya.R. Kovalenko of the Russian Academy of Sciences
Russian Federation

Engasheva E. S. – Doctor of Biology, Scientific sotr. lab. Pharmacology and Toxicology



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For citations:


Engashev S.V., Novak M.D., Novak A.I., Evdokimova O.V., Engasheva E.S. SENSITIVITY OF BACTERIA TO ANTIBIOTICS MASTI BLOCK® DC 49, MASTIC-P, MASTERCARD WITH MASTITIS OF DRY COWS. International Journal of Veterinary Medicine. 2024;(4):161-171. (In Russ.) https://doi.org/10.52419/issn2072-2419.2024.4.161

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