Correlation indicators between pharmacokinetic parameters of caffeine in clinically healthy laboratory and farm animals
https://doi.org/10.52419/issn2072-2419.2024.4.185
Abstract
Correlation analysis is an important tool in veterinary medicine, since it allows us to study the relationships between various indicators of animal health and the results of diagnostic tests, which allows us to confirm or reject the relevance of various biomedical hypotheses. The relevance of this method is due to the need to confirm the reliability of diagnostic models, which, in turn, helps to improve the accuracy of disease diagnosis, as well as the introduction of new similar methods with high prognostic value. Veterinary practice requires a high degree of reliability in the results, since incorrect diagnosis can lead to serious consequences for the health of animals. The pharmacokinetic parameters of caffeine in clinically healthy laboratory animals and cattle were used as material for the study. Correlation relationships between caffeine concentration (for equivalent time intervals), total plasma clearance, average residence time of the substance, and distribution volume were analyzed. For a complete analysis, parametric (Pearson correlation coefficient) and nonparametric (Spearman rank correlation coefficient) correlation indicators were used. The correlation coefficients we used to analyze relationships in pharmacokinetic studies show ambiguous results when comparing exogenous caffeine in two animal species. Despite the presence of similar correlation features, stable relationships were not established, which indicates the complexity of interactions and individual interspecies characteristics. In addition, differences in responses between males and females also do not show pronounced stability, which may be due to differences in metabolism and physiological characteristics. Thus, future studies should include the study of pharmacokinetic parameters in other animal species to provide more accurate predictions and improve understanding of metabolic processes associated with caffeine. This will allow the creation of reliable and universal methods for assessing the state of the hepatobiliary system in various animals.
Supporting agencies: The study was supported by the Russian Science Foundation Grant No. 23-26-00011, https:// rscf.ru/project/23-26-00011.
About the Authors
V. S. Ponamarev
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Ponamarev V.S. – Ph.D. of Veterinary Science, Associate Professor Department of Pharmacology and Toxicology
A. V. Kostrova
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Kostrova A.V. – Assistant Professor of Pharmacology and Toxicology
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Review
For citations:
Ponamarev V.S., Kostrova A.V. Correlation indicators between pharmacokinetic parameters of caffeine in clinically healthy laboratory and farm animals. International Journal of Veterinary Medicine. 2024;(4):185-193. (In Russ.) https://doi.org/10.52419/issn2072-2419.2024.4.185
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