POPULATION-GENETIC CHARACTERISTICS OF CATTLE BY THE MC4R (MELANOCORTIN 4 RECEPTOR) GENE
https://doi.org/10.52419/issn2072-2419.2024.4.518
Abstract
The aim of the work was to provide a population genetic characteristic of the Kholmogorsky breed of the Tatarstan type of the Republic of Tatarstan for the MC4R gene (melanocortin 4 receptor). As a result of genotyping by the PCR-RFLP method for the MC4R - HpySE526I gene locus, 2 alleles and 3 genotypes were identified. The frequency of alleles: C - 0.434 and G - 0.566; and frequency of genotypes: CC - 20.9, CG - 45.0 and GG - 34.1%. The chi-square test (χ²) showed that the studied population the Hardy–Weinberg genetic equilibrium is not disturbed. A negative Selender coefficient (D) indicates outbreeding in the population. Monitoring of works on studying the polymorphism of the gene 1069C˃G (Leu286Val) shows a significant variability in the ratio of polymorphic forms of the MC4R gene in different cattle populations depending on their geographic and breed affiliation. On average, for all the considered cattle breeds of the world populations, the frequency of alleles of the MC4R gene is 0.537 and 0.463 for the allele C and G, respectively. The ratio of the CC, CG and GG genotypes of the MC4R gene for all analyzed cattle populations averaged 32.5, 42.3 and 25.2%. The analysis carried out using the data of foreign scientists and the results obtained in our study characterizes the world populations of cattle as genetically biodiverse, possessing genetic polymorphism for the MC4R gene with a high degree of heterozygosity. This research was supported by FASO Russia project, registration number 122011800138-7.
Supporting agencies: This research was supported by the Ecological and genetic approaches to the creation and conservation of plant and animal resources, the expansion of their adaptive potential and biodiversity, the development of conservation agrotechnologies to increase the sustainability of high-quality products, achieve safety for human health and the environment. FASO Russia project. Registration number: 122011800138-7.
About the Authors
N. Yu. Safina
Tatar Scientific Research Institute of Agriculture “Kazan Scientific Center of Russia Academy of Sciences”
Russian Federation
Russian Federation
Safina N.Yu. – Candidate of Biological Sciences, Senior Researcher
E. O. Krupin
Tatar Scientific Research Institute of Agriculture “Kazan Scientific Center of Russia Academy of Sciences”
Russian Federation
Russian Federation
Krupin E.O. – Doctor of Veterinarian Sciences, Leading Researcher
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Review
For citations:
Safina N.Yu., Krupin E.O. POPULATION-GENETIC CHARACTERISTICS OF CATTLE BY THE MC4R (MELANOCORTIN 4 RECEPTOR) GENE. International Journal of Veterinary Medicine. 2024;(4):518-527. (In Russ.) https://doi.org/10.52419/issn2072-2419.2024.4.518
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