THE INFLUENCE OF THE NATURAL ADAPTOGEN BETULIN ON THE CLINICAL AND HEMATOLOGICAL PARAMETERS OF CALVES OF THE BREEDING HERD
https://doi.org/10.52419/issn2072-2419.2024.4.566
Abstract
The immunostimulating activity of betulin is manifested in the ability to induce the production of endogenous interferon in the body, as well as to increase cellular and humoral immunity, enhance the activity of some immunocompetent cells, in particular activating all indicators of phagocytosis (the ability of phagocytes to destroy viruses and bacterial cells). The purpose of the study is to study the effect of betulin on the clinical status and hematological indicators of breeding calves. The studies were conducted in the dairy complexes of the breeding farm of the Agricultural Enterprise Kolkhoz "Soznatelny", Zubtsovsky District, Tver Region, on the basis of the Department of Disease Diagnostics, Therapy, Obstetrics and Reproduction of Animals and the Treatment and Diagnostic Center of the Federal State Budgetary Educational Institution of Higher Education Moscow State Academy of Veterinary Medicine and Biotechnology - Moscow State Academy of Veterinary Medicine named after K.I. Skryabin (hereinafter referred to as the PH). Betulin was given to each animal of the group orally at a dose of 10 mg / kg of weight with water individually 1 time per day for 14 days. To assess the effect of betulin on the body of experimental animals, as well as to exclude concomitant diseases, a clinical study of all experimental animals and a hematological analysis were conducted at the beginning and end of the experiment. An automatic hematological analyzer Abacus Junior Vet (Austria) was used to conduct clinical blood tests. The number of erythrocytes, leukocytes, platelets, lymphocytes, basophils, monocytes, eosinophils, segmented neutrophils was calculated, as well as the hemoglobin level, color index, anisocytosis index, and hematocrit value were determined. The results of the effect of betulin on hematological indices of five-month-old breeding calves showed that the preparation causes a reliable increase in the number of peripheral blood lymphocytes (p≤0.01), eliminates the phenomenon of neutrophilic leukocytosis, reducing the number of neutrophils (p≤0.05) and the total number of leukocytes (p≤0.01) to the physiological norm. Thus, it can be assumed that the drug "Betulin" stimulates active reproduction of lymphocytes, enhances phagocytosis, which leads to the relief of the inflammatory process and a decrease in the number of neutrophils.
Keywords
About the Authors
L. A. GnezdilovaRussian Federation
Gnezdilova L.A. – Doctor of Veterinary Sciences, Professor, Head of the Department of Disease Diagnostics, Therapy, Obstetrics and Reproduction of Animals
Yu. S. Kruglova
Russian Federation
Kruglova Yu.S. – Candidate of Veterinary Sciences, Associate Professor of the Department of Disease Diagnostics, Therapy, Obstetrics and Reproduction of Animals
Zh. Yu. Muradyan
Russian Federation
Muradyan Zh.Yu. – Candidate of Biological Sciences, Associate Professor of the Department of Disease Diagnostics, Therapy, Obstetrics and Reproduction of Animals
S. M. Rozinsky
Russian Federation
Rozinsky S.M. – Assistant of the Department of Disease Diagnostics, Therapy, Obstetrics and Reproduction of Animals
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Review
For citations:
Gnezdilova L.A., Kruglova Yu.S., Muradyan Zh.Yu., Rozinsky S.M. THE INFLUENCE OF THE NATURAL ADAPTOGEN BETULIN ON THE CLINICAL AND HEMATOLOGICAL PARAMETERS OF CALVES OF THE BREEDING HERD. International Journal of Veterinary Medicine. 2024;(4):566-577. (In Russ.) https://doi.org/10.52419/issn2072-2419.2024.4.566