Pseudoeosinophilic phagocytosis of chicken blood under the influence of different doses of Enrofloxacin in experimental salmonellosis

The aim of the study was to investigate the effect of different doses of enrofloxacin on the indices of phagocytosis of pseudoeosinophils in the blood of chickens under conditions of experimental salmonellosis. The effect of enrofloxacin in doses of 200 mg/l and 100 mg/l on the phagocytosis of pseudoeosinophils in the blood of chickens was studied. Enrofloxacin is an antibacterial drug of the fluoroquinolone group used in veterinary medicine. The use of this medicinal product is most widely represented in poultry farming, due to its excellent pharmacodynamic and antimicrobial properties. The aim of this work is to study the effect of enrofloxacin on pseudoeosinophil phagocytosis in experimental salmonellosis caused by Salmonella infantis culture. The study involved four groups consisting of day-old chicks of the Haysex Brown cross. Chickens of group I (intact control) received pure water, while in groups III and IV, enrofloxacin was drunk for 5 days with water at doses of 200 mg/l and 100 mg/l, respectively. Blood sampling was performed on the second, fourth, sixth, eighth and tenth days after drug withdrawal. Phagocytic activity, phagocytic number, phagocytic index, and phagocytic capacity of pseudoeosinophils were studied after co-incubation for 30 and 120 minutes with Staphylococcus aureus culture. The effect of enrofloxacin at a dose of 200 mg/l was manifested in a short-term increase in phagocytic activity, phagocytic index, and phagocytic capacity of pseudoeosinophils after 30 minutes of exposure. The most significant changes in phagocytic activity, phagocytic index, and phagocytic capacity of pseudoeosinophils were detected in experimentally infected groups receiving enrofloxacin at a dose of 100 mg/l, as well as pure water. All registered changes were shortlived.

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