The effect of the drug "Prostimul" on the formation of intestinal microbiome and mitotic activity of cells of the small division intestines of piglets with prenatal hypotrophy

A significant problem of modern industrial pig farming is the birth of a significant number of piglets with low live weight. A major problem is the further preservation and viability of physiologically immature piglets. The article describes the results of studies aimed at evaluating the effect of a stimulating drug based on recombinant cytokines of the first and second types (interferon alpha and interferon gamma), as well as vitamins A, E, and C – the drug Prostimuli – on the formation of the intestinal microbiome, as well as the mitotic activity of cells in the small intestine of piglets with perinatal hypotrophy. The experiment used newborn piglets, which were divided into 3 groups: group 1 — healthy piglets (n=10); group 2 — hypotrophic piglets (n=10), which per os, in addition to the main colostrum ration, were given cow colostrum at a dosage of 2.5 ml per head for 3 days (the scheme used in agriculture); group 3 — hypotrophic piglets (n=10), which were given parenteral Prostimul twice, in the first and third days of life at a dose of 0.1 ml / kg of body weight. On the 7th day of the piglets' life, fecal samples and small intestine samples were taken for research. According to the results of the conducted studies, it was found that the use of the drug Prostimul in piglets with perinatal hypotrophy contributes to the normalization of intestinal microflora due to the action of interferon alpha on pathogenic microorganisms, which can be used as a means of preventing colibacteriosis, and also allows to stimulate morphogenesis in the small intestine and, consequently, activate the processes of nutrient absorption, which stimulates more active growth of piglets.- hypotrophics.

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