Investigation of biochemical parameters of rainbow trout against the background of the use of probiotic drugs

In highly productive fish farming, antibiotics are still the only way to prevent and treat infectious diseases. The use of antibiotics is not always rational, often accompanied by the formation of multiple drug resistance in pathogens, affects the ecological state of the reservoir and the safety of farmed fish products for humans. Many antibacterial drugs accumulate in individual organs and tissues and remain stable even after cooking the fish. Currently, the need for drugs with adaptogenic properties can be associated with changes in the situation on the feed additives market, a shortage of domestic effective nutraceuticals and biologically active substances, including vitamins, mineral complexes, dietary fiber, pro- and prebiotics. The aim of the study was to study the effect of various probiotic supplements in the diet of rainbow trout (Oncorhynchus mykiss) on the biochemical status of its body. Blood biochemical parameters (ALT, AST, ALP activity, total bilirubin, total protein, albumin, creatinine, urea, glucose, cholesterol) were determined using an automatic Chem Well biochemical analyzer (Awareness Technology, USA). The studies revealed that the studied probiotic preparations do not have a hepatotoxic and nephrotoxic effect, as indicated by the absence of reliable changes in biochemical parameters characterizing the functioning of the liver and kidneys, but have a positive effect on the protein metabolism of fish. Thus, we can conclude that the experimental probiotic preparations based on strains of bacteria of the genus Lactobacillus have a positive effect on the metabolism of rainbow trout. The results of the studies can also be used to optimize the composition of production feed for rainbow trout.

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