Changes in serum amyloid A of cats and C-reactive protein of dogs in pneumonia
https://doi.org/10.52419/issn2072-2419.2025.2.391
Abstract
A full-fledged diagnosis of pneumonia should include testing for the level of acutephase inflammatory proteins. C-reactive protein is widespread in dogs, and its concentration increases as early as 6-8 hours after the onset of inflammation. Cats have serum amyloid A, whose concentration increases 24-48 hours after the onset of inflammation. Currently, the immunofluorescence method is widely used to determine acutephase inflammatory proteins. The authors compared the levels of acute-phase inflammatory proteins in healthy animals and sick animals (before and after treatment). A statistically significant difference was revealed between patients before treatment and healthy animals. A statistically significant difference was found between recovered and healthy cats. There were no statistically significant differences between recovered and healthy dogs. The level of serum amyloid A in sick cats significantly increased 8-fold relative to healthy ones (p<0.01), and upon recovery returned to the standard values, but was significantly higher by 32.6% than in healthy animals (p><0.01). The level of Creactive protein in sick dogs significantly increased by 7.6 times relative to healthy dogs (p><0.01), and upon recovery returned to the standard values and had no significant difference with healthy animals. Determining the concentration of C-reactive protein in dogs and serum amyloid A in cats before starting therapy and after antibiotic therapy helps to decide whether to extend treatment if necessary and is one of the criteria for the success of therapy. > < 0.01), and upon recovery returned to the standard values, but was significantly higher by 32.6% than in healthy animals (p < 0.01). The level of Creactive protein in sick dogs significantly increased by 7.6 times relative to healthy dogs (p < 0.01), and upon recovery returned to the standard values and had no significant difference with healthy animals. Determining the concentration of C-reactive protein in dogs and serum amyloid A in cats before starting therapy and after antibiotic therapy helps to decide whether to extend treatment if necessary and is one of the criteria for the success of therapy.
About the Authors
Yu. V. Gradova
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
postgraduate student
S. P. Kovalev
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Doctor of Veterinary Sciences, Professor, Head of the Department of Clinical Diagnostics
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For citations:
Gradova Yu.V., Kovalev S.P. Changes in serum amyloid A of cats and C-reactive protein of dogs in pneumonia. International Journal of Veterinary Medicine. 2025;(2):391-396. (In Russ.) https://doi.org/10.52419/issn2072-2419.2025.2.391
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