Dynamics of the level of circulating immune complexes in blood serum in rabbits under model stresses

Abstract

A small amount of circulating immune complexes is determined in a healthy body, and it naturally increases when there is an antigen in the circulation. Stressful situations can inhibit the implementation of immune protection, both adaptive and innate immune responses. The purpose of this study was to study the dynamics of the level of circulating immune complexes in blood serum after modeling single and combined stress effects in rabbits. 10 male rabbits were used for the experiment. The animals were 8 months old and had a live weight of 3.40±0.73 kg. Transport stress was caused by transporting animals in a car. Immobilization stress was modeled by fixing rabbits in a fixation device for small animals by their legs in the dorsal position. In the final series of experiments, a combination of actions was performed (immobilization, then, after three days, transportation). As a result of studies it was found that the reaction of animals to stress was characterized by decreased level of the CIC, during transportation (by 1.2 times (p<0.05) and immobilization (1.6 times, p<0.05), the combination of stress factors showed a similar effect. In the poststress period, we observed in all cases an increase in the CIC level in the blood of rabbits, which exceeded the CIC values both at the time of the stress reaction and the level of intact animals.