The effect of the drug "Hepaton" on the reaction of lipid peroxidation

Abstract

The composition of the drug "Hepaton" includes many bioactive compounds that provide the antioxidant properties of the drug, manifested by the neutralization of reactive oxygen species (ROS) with the breakaway chain free radical reactions. The aim of the study was to determine the effect of the Hepaton preparation on lipid peroxidation reactions in laboratory rats. Evaluation of the antioxidant effect of the drug was carried out on twenty laboratory rats of both sexes with a body weight of 180-220 g, divided into 2 groups. Acute toxic hepatitis in rats was induced by a single intragastric administration of 1.0 ml of a dichloroethane solution. At the same time, rats of the experimental group (n = 10) 1 hour before the introduction of dichloroethane were injected with a solution of the drug “Hepaton” in the amount of 10 ml / kg body weight and then 1 time per day for 21 days after the use of toxicants [1]. On the 21st day after the administration of toxicants, a blood was drawn for a biochemical study, which took into account the parameters of the antioxidant system (diene conjugates (DC), ketodienes (CD) and malondialdehyde (MDA), as well as the level of endogenous intoxication (according to the content of MSM). Based on the results obtained, it can be concluded that the use of “Hepaton” in modeling acute toxic hepatitis made it possible to restore the disturbed homeostasis of the laboratory animal organism, the structure and integrity of the hepatocyte membranes, inhibit lipid peroxidation as one of the links in the pathogenesis of hepatitis, stimulate antioxidant defense and power the endogenous antioxidant system of the body, bile formation and biliary excretion, as well as activate the reparative processes of the liver tissue at the cellular and intracellular levels.