Pathological changes with the enteropathy caused by difillobotriosis in dogs

Pathomorphological research of dogs intestine allowed us to describe in more detail all encountered cases of pathological manifestation and effect of broad tapeworm on different tissue structures and their fragments. Enteropathies are polymorphous and are introduced with different etiological factors. Intestine helminthiases have heavy share of ethiofactors. Microscopic signs of intestinal lesion of dogs during diphyllobothriasis were characterized with obvious changes in mucosa and submucosa and their damage pathological changes in a smooth muscle layer were rarely noted. Serous coat and all its structural fragments complied with the norm and didn't have pathological. Extensive zones of damage from mehanical injury were not noted,there were areas of gut wall changes with damage and intestinal villi destruction and epithelial membrane destruction possibly caused by morphological and physiological structural features of the parasite. Characteristic pathological signs were symptomatic desquamation of tessellated epithelium. Extensive damage of serous coat tracedin all the microslides prepared for histologic study. All these changes can be a possible reason of development of reduction of nutrient intake. Such kind of research as pathological process encourages more detailed identifying of clinical status during diphyllobothriasis and its not characteristic or specific manifestations and will be the additional criteria of high-impact therapeutics or its evidence.

энтеропатии, лентец широкий, дифиллоботриоз, патологическая анатомия, деструкция ворсинок эпителия, enteropathy, Diphyllobothrilim latum, diphyllobothriosis, pathological anatomy, destruction of epithelium villi

1. ГОСТ Р 57547-2017 Патологоанатомическое исследование трупов непродуктивных животных. Общие требования [Электронный ресурс]. - М: Стандартинформ, 2017. - 15 С. - Режим доступа: http://docs.cntd.ru/document/1200146266.

2. Ладыгина, А.С. Дифиллоботриоз в архангельской области: исторический аспект и современная ситуация / А.С. Ладыгина, Н.А. Бебякова, И.А. Шабалина, Т.В. Балаева, К.О. Титарчук // Известия Коми научного центра УрО РАН. - 2019. - № 2 (38). - С. 41-46.

3. О состоянии санитарноэпидемиологического благополучия населения в Российской Федерации в 2018 году: Государственный доклад.-М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, 2019.-254 С.

4. Шинкаренко, А.Н. Зараженность хищных рыб водоемов Волгоградской области / А.Н. Шинкаренко, С. Н. Федоткина // Теория и практика паразитарных болезней животных. - 2014. - № 15. - С. 351-354

5. Chandra, L. Derivation of adult canine intestinal organoids for translational research in gastroenterology / L. Chandra, D.C. Borcherding, D. Kingsbury, et al. // BMC Biol. - 2019. - Vol. 17(1). - P. 33

6. Gianella, P. Clinicopathologic and prognostic factors in short- and long-term surviving dogs with protein-losing enteropathy / P. Gianella, U. Lotti, C. Bellino, et al. // Schweiz Arch Tierheilkd. - 2017. - Vol. 159 (3). - P. 163-169

7. Gladwin, N.E. Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs / N.E. Gladwin, D.G. Penninck, C.R. Webster // American Journal of Veterinary Research. - 2014. -Vol. 75(4). - P. 349-53.

8. Heilmann, R.M. Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs / R.M. Heilmann, J.M.Steiner // J Vet Intern Med. - 2018. -Vol. 32(5). - P. 1495-1508

9. Histopathological Standards for the Diagnosis of Gastrointestinal Inflammation in Endoscopic Biopsy Samples from the Dog and Cat: A Report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group / M.J. Day, T. Bilzer, J. Mansell, B. Wilcock // Journal of Comparative Pathology. - 2008. - Vol. 138 (1). - P. 1-43

10. Menozzi, A. Rifaximin is an effective alternative to metronidazole for the treatment of chronic enteropathy in dogs: a randomised trial / A. Menozzi, M. Dall’Aglio, F. Quintavalla, et al. // BMC Vet Res. - 2016. - Vol. 12(1). - P. 217