Consequences of chronic renal insufficiency in dogs

Abstract

Chronic renal failure (CRF) in dogs develops on the background of chronic inflam matory diseases of the kidneys. CPS occurs in four stages: latent, latent, compensated insufficiency, decompensation and terminal. Chronic renal failure leads to intoxication of the whole organism and negatively affects the functional state of other internal organs and systems. The study of clinical blood test found an increase in ESR, which indicates the development of the inflammatory process, and the reduction of hemoglobin, hematocrit and the presence of reticulocytes in the blood indicates anemia. HPN in dogs leads to the development of intoxication, which is confirmed by the calculation of leukocyte intoxication indices (on the Flight, the index of the ratio of leukocytes and ESR, Krebs index, the nuclear index, the reactive response of neutrophils). Biochemical study of blood serum showed an increase in creatinine and urea levels, an increase in amylase activity, which indicates a decrease in glomerular filtration rate. The increase in phosphorus levels and reduced calcium levels in the blood serum leads to hypocalcemia. The de Ritis coefficient was at the lower limit of reference values, the activity of AST was increased, and the activity of ALT -within reference values, indicating damage to hepatocytes. In chronic renal failure in dogs with clinical and biochemical examination of urine were observed proteinuria, leukocyturia, erythrocyturia low value of specific gravity, crystalluria. Thus chronic renal failure in dogs contributes to the development of intoxication, narasaraopet, liver function and calcium-phosphorus metabolism.