Piglet blood parameters during the administration of swine recombinant interferon and enrofloxaferon-C
Abstract
The aim of the study is to test preparations containing the species-specific interferon "Recombinant porcine interferon" and the species-specific interferon with enrofloxacin "Enrofloxaferon-S" produced by OOO NPTs BelAgroGen for the prevention and treatment of respiratory diseases in piglets in the conditions of technological maintenance.
The experiment was carried out at the Vostochny pig breeding complex LLC, the Republic of Udmurtia. The animals were kept in the same zoohygienic conditions, had the same feeding ration, according to age and feeding technology. For feeding animals, a compound feed that does not contain antibacterial components is used. During the experiment, two experimental and control groups of piglets were formed at the age of 129 - 144 days, average weight 50 - 63 kg, according to the principle of analogues. When setting up the experiment, the groups were formed from animals with signs of diseases of the respiratory system. After 5 days of the experiment, a blood test was carried out for a number of indicators - biochemical, immunological, hormonal.
Analysis of clinical indicators shows that piglets receiving IRS and enrofloxaferon-C stabilized by the seventh and sixth days of the experiment, respectively.
As a result of the use of drugs, fat and protein metabolism has increased, which is confirmed by an increase in the level of cholesterol, urea, there is a significant load on the hepatobiliary system of the liver.
There is a decrease in the level of total protein, an increase in the albumin fraction and a decrease in globulins. Similar results indicate profound immunosuppression in the development of diseases of the respiratory system.
Analyzing hormonal indicators, we observe a decrease in the level of TSH, the level of T4 is growing simultaneously and actively, the level of T3 remains stable. This picture characterizes the activation of the functions of the pituitary gland, the thyroid gland, the activation of metabolic processes, the work of the liver, and increased protein metabolism.
Based on the results of the experiment, we recommend using the interferon preparations "Porcine interferon recombinant" and "Enrofloxaferon-S" for the treatment of piglets with respiratory diseases, since they provide the most optimal data on the level of the studied parameters.
About the Author
T. I. Reshetnikova
Federal state budget institution of higher education «National research Mordovian state University N. P. Ogareva» FGBOU VO «Mordovia Ogarev State University»
Russian Federation
Russian Federation
PhD in Veterinary Sciences, Associate Professor,
Republic of Mordovia
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For citations:
Reshetnikova T.I. Piglet blood parameters during the administration of swine recombinant interferon and enrofloxaferon-C. International Journal of Veterinary Medicine. 2021;(1):99-107. (In Russ.)
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