Peculiarities of rats metabolism with femoral bone fractures at the background of immunocorrection and application of biocomposition material. Report 1. dynamics of protein, nitrogen and carbohydrate metabolism indicators

Abstract

The article is devoted to the investigation of the effect of two drugs from the groups of:immunomodulators - a synthetic dipeptide (drug RV-2) and biocomposition materials (drug RVI) on metabolic processes (protein, nitrogenous, carbohydrate metabolism) of laboratory rats with fractures of tubular bones.

The paper presents data on the nature of laboratory animals (rats) body repair after trauma, accompanied by a significant increase in the level of biochemical indicators of the bloode (total protein, albumin, globulins, urea, creatinine, glucose, a change in the albumin-globulin ratio).

The most pronounced (tangible) changes were recorded on the 7th, 21st and 45th days of the post surgery period, which essentially correlates in time with the phases of fracture healing. Along with this, it was found that such fluctuations in biochemical parameters, changes depend not only on the stages of the osteoreparative process, but also on the type of drugs, methods and schemes of their use. This statement was confirmed in experiment on five groups of experimental animals compared with the control ones when using the RVI and RV-2 preparations in various variants - separately or in combination, as well as using only one immunomodulator, depending on the time - in the first five days or on the fifth day of post surgery period.

It was shown that the combined use of the biocomposite together with immunocorrection drug during the first five days after the operation was the most effective. Such scheme makes it possible to reduce the primary inflammatory load in the affected tissues to a significant extent, to provide osteoregeneration and restoration of the motor activity of the muscles of animals.