The effect of various thermostable antigens on the formation of local mammary gland immunity

Abstract

At the moment, methods aimed at activating the endogenous defense mechanisms of animals, seem to be promising in the prevention and treatment of mastitis. One of them is the method of local antigenic stimulation. Its advantages include a fairly long period of protection from the disease, the absence of any effect on the dairy products obtained, and, most importantly, the absence of adaptive mechanisms in the causative agents of mastitis. The primary link in the formation of local immunity of the mammary gland is antigen-presenting cells of a makrophageal nature, it’s role is presumably perceive the action of thermostable antigens and induce a further reaction of the immune system. This article discusses the formation of local immune response in the mammary glands of experimental mice. The main goal of this study was to compare the indicators obtained as a result of the treatment of mice with various thermostable antigens and the indicators of non-immunized individuals. Based on the results of the experiment, we obtained data showing that the number of macrophages in immunized mice in all experimental groups significantly exceeds the number of macrophages in mice in the control group. Our studies allow us to reveal some aspects of the mechanism of action of the studied method of treating mastitis, which opens up further prospects for recommending it for mass use in veterinary practice, since the number of macrophages in immunized mice of the experimental group significantly exceeds the number of macrophages in untreated mice of the control group.