Leukocyte indices as markers of chronic adaptation processes in rabbits
Abstract
The article presents data on the dynamics of leukocyte parameters depending on the tension of the regulatory systems of the organism of rabbits with a cellular content with a mesh floor. The research was carried out on the basis of the educational and scientific laboratory of rabbit breeding of the Belgorod State Agrarian University. The object of the study was silver rabbits aged from 5 to 8 months (n = 15). Counting the total number of leukocytes and leukocyte formula was carried out according to generally accepted methods. To establish changes in white blood, according to the classification of the adaptation process according to the degree of tension of the regulatory systems of the body proposed by Baevsky R.M., 1979, the ani mals were divided into groups: I - physiological norm, II - With signs of tension of regulatory mechanisms, manifested by the presence on the plantar surfaces of the feet of the hind limbs of alopecia, white callus, hyperkeratosis; III - with signs of tension in regulatory mechanisms, characterized by the development of extensive alopecia on the plantar surface of the feet of the hind limbs and obvious hemorrhagic changes in the area of callus development.
Stage 1 of adaptation is characterized by the absence of any deviations from the normative values, the second stage of the adaptation process is accompanied by changes in leukocyte indices and leukogram, characterizing a decrease in immune responses. The presence of hemorrhages in the area of alopecia and calcification of the supporting surface of the feet indicates the development of the third stage of the adaptation process, in which the factors of nonspecific resistance of the organism are activated and the development of autointoxication, as indicated by leukocyte indices and leukoformula indicators. These changes lead to the development of a premorbid state. The search for markers of the development of homeostasis disorders allows taking into account the response to endogenous and exogenous factors, accordingly predicting the outcome of pathological processes and developing preventive measures.
About the Authors
N. S. Khokhlova
FSBEI HE Belgorod State Agrarian University named after V.Ya. Gorina
Russian Federation
Russian Federation
applicant, head of the rabbit breeding laboratory
V. V. Semenyutin
FSBEI HE Belgorod State Agrarian University named after V.Ya. Gorina
Russian Federation
Russian Federation
Doctor of Biological Sciences, Senior Researcher
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For citations:
Khokhlova N.S., Semenyutin V.V. Leukocyte indices as markers of chronic adaptation processes in rabbits. International Journal of Veterinary Medicine. 2021;(2):199-205. (In Russ.)
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