Preview

International Journal of Veterinary Medicine

Advanced search

Assessment of the rabbit meat quality and safety when using marbotrim

https://doi.org/10.17238/issn2072-2419.2021.3.108

Abstract

One of the representatives of the third generation fluoroquinolones is marbofloxacin. It was also found that the combined use of trimethoprim and fluoroquinolones has a synergistic effect, which gives good results in the treatment of concomitant infections of the respiratory and gastrointestinal tract [6]. Therefore, the combination of marbofloxacin and trimethoprim in one preparation is very attractive. However, for the introduction of the drug into veterinary practice, a prerequisite is the conduct of preclinical and clinical studies. The research was carried out in the conditions of the vivarium of the Federal State Budgetary Scientific Institution "VNIVIPFiT". The objective of the research was to study the effect of marbotrim on the meat quality. The experiment included 10 rabbits of the Soviet chinchilla breed with a live weight of 2.7-3.0 kg, which were divided into 2 groups. Group 1 (n = 5) was the control and the animals were not administered the drug, the animals of group 2 (n = 5) were injected intramuscularly with the drug marbotrim at a therapeutic dose (0.02 ml/kg) once a day for 3 days according to the instructions for application. A day after the last injection of the drug, a diagnostic slaughter was carried out, followed by a veterinary and sanitary examination of the meat of all animals. It has been found that intramuscular administration of marbotrim at a therapeutic dose does not have a negative effect on the organoleptic and physicochemical indicators of meat quality.

About the Authors

N. A. Grigoryeva
FSBSI “All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy”
Russian Federation

PhD of Veterinary Sciences., Senior Scientific Associate



M. S. Zhukov
FSBSI “All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy”
Russian Federation

Candidate of Veterinary Sciences, Senior Scientific Associate



D. I. Shabanov
FSBSI “All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy”
Russian Federation

Junior Scientific Associate



A. A. Veli
FSBSI “All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy”
Russian Federation

Junior Scientific Associate



M. S. Bogdanova
FSBSI “All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy”
Russian Federation

Postgraduate Student



References

1. Анализ эффективности антимикробных препаратов в отношении бактериальных возбудителей маститов коров / Пархоменко Ю.С. Манжурина О.А., Семенова Е.В. и др. // Ветеринарный фармакологический вестник. – 2020. – №2 (11). – С. 133-142. DOI: 10.17238/issn2541-8203.2020.2.133.

2. Жуков М.С. Рациональные подходы к стартовой антибактериальной терапии болезней органов дыхания у телят / М.С. Жуков, О.А. Манжурина, Ю.С. Пархоменко // Вопросы нормативно-правового регулирования в ветеринарии. – 2019. – №3. – С. 41-44. DOI: 10.17238/issn2072-6023.2019.3.41.

3. Изучение уровня экспрессии генов ферментов рестрикции ДНК микроорганизмов при формировании антибиотикорезистентности / Г.А. Востроилова, Н.В. Пасько, А.О. Королькова и др. // Ветеринарный фармакологический вестник. – 2018. – №3 (4). – С. 18-23. DOI: 10.17238/issn2541-8203.2018.3.18

4. Изучение эффективности антибактериальных препаратов к бактериальным возбудителям воспалительных заболеваний репродуктивных органов свиноматок / О.А. Манжурина, Ю.С. Пархоменко, И.С. Перепёлкина, Е.В. Семенова // Материалы V-го Международного конгресса ветеринарных фармакологов и токсикологов. Санкт-Петербург, 2019. – С. 120-122.

5. Исследования резистентности бактериальных возбудителей желудочнокишечных и респираторных болезней поросят к антимикробным препаратам / А.Г. Шахов, Л.Ю. Сашнина, М.И. Лебедев, Е.В. Лебедева // Доклады Российской академии сельскохозяйственных наук. – 2011. – №2. – С. 53-55.

6. Одновременное определение триметоприма, энрофлоксацина и ципрофлоксацина в сыворотке крови птицы / А.С. Кубасов, П.П. Кочетков, А.В. Балышев, С.В. Абрамов, В.Е. Абрамов // Журнал аналитической химии. – 2016. – Т. 71. – №6. – С. 667-670.

7. Сидоренко С.В. Фторхинолоны: свойства и клиническое применение / С.В. Сидоренко // Трудный пациент. – 2011. – Т. 9. – № 5. – С. 21-27.

8. Fluoroquinolonemetal complexes: a route to counteract bacterial resistance? / M.J. Feio, I. Sousa, M. Ferreira et al. // J. Inorg. Biochem. – 2014. – Vol. 138. – P. 129-143.

9. Non-clinical studies in the process of new drug development - Part II: Good laboratory practice, metabolism, pharmacokinetics, safety and dose translation to clinical studies / E.L. Andrade, A.F. Bento, J. Cavalli et al // Braz J Med Biol Res. – 2016. – Vol. 49(12). – e5646.


Review

For citations:


Grigoryeva N.A., Zhukov M.S., Shabanov D.I., Veli A.A., Bogdanova M.S. Assessment of the rabbit meat quality and safety when using marbotrim. International Journal of Veterinary Medicine. 2021;(3):108-112. (In Russ.) https://doi.org/10.17238/issn2072-2419.2021.3.108

Views: 217


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2072-2419 (Print)